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CLDN1 / Claudin 1

claudin 1

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391). CLDN1 acts as a coreceptor for HCV entry into hepatic cells.

Gene Name: claudin 1
Family/Subfamily: Claudin , not assigned-Claudin
Synonyms: CLDN1, Claudin-1, Claudin 1, ILVASC, SEMP1, CLD1
Target Sequences: NM_021101 NP_066924.1 O95832

Publications (8)

1
Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature. Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Diagnostic pathology. 2014 9:163. (IHC; Human) [Full Text Article] [PubMed:25183312] [PMC:PMC4167136] Related Antibodies: LS-B6327.
2
Satellite cells maintain regenerative capacity but fail to repair disease-associated muscle damage in mice with Pompe disease. Schaaf GJ, van Gestel TJM, In 't Groen SLM, de Jong B, Boomaars B, Tarallo A, Cardone M, Parenti G, van der Ploeg AT, Pijnappel WWMP. Acta neuropathologica communications. 2018 November;6:119. [Full Text Article] [PubMed:30404653] [PMC:PMC6220463] Related Antibodies: LS-C6142.
3
A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence. Kaifan Bao, Weiyuan Yuan, Yijing Zhou, Yanyan Chen, Xuerui Yu, Xiaoyu Wang, Zhirong Jia, Xi Yu, Xiaotong Wang, Lu Yao, Siqi Wang, Yifan Xu, Yuheng Zhang, Jie Zheng, Min Hong. Frontiers in pharmacology. 2020 February;10:1698. [Full Text Article] [PubMed:32076408] [PMC:PMC7006455]
4
Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models. Hannah M Hollandsworth, Thinzar M Lwin, Siamak Amirfakhri, Filemoni Filemoni, Surinder K Batra, Robert M Hoffman, Punita Dhawan, Michael Bouvet. The Journal of surgical research. 2019 October;242:145-150. [Full Text Article] [PubMed:31077946] [PMC:PMC7144806] Related Antibodies: LS-C382732.
5
Toll-like receptor 2 stimulation augments esophageal barrier integrity. Melanie A Ruffner, Li Song, Kelly Maurer, Lihua Shi, Margaret C Carroll, Joshua X Wang, Amanda B Muir, Jonathan M Spergel, Kathleen E Sullivan. Allergy. 2019 December;74:2449-2460. [Full Text Article] [PubMed:31267532] [PMC:PMC7083217]
6
Indol-3-Carbinol and Quercetin Ameliorate Chronic DSS-Induced Colitis in C57BL/6 Mice by AhR-Mediated Anti-Inflammatory Mechanisms. Sina Riemschneider, Maximilian Hoffmann, Ulla Slanina, Klaus Weber, Sunna Hauschildt, Jörg Lehmann. International journal of environmental research and public health. 2021 Feb;18:2262. [Full Text Article] [PubMed:33668818] [PMC:PMC7956562] Related Antibodies: LS-B6327.
7
Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X. Gut. 2014 May;63:711-9. [Full Text Article] [PubMed:23676441] [PMC:PMC3883925] Related Antibodies: LS-B6327.
8
Gastroesophageal reflux activates the NF- kappa B pathway and impairs esophageal barrier function in mice. Fang Y, Chen H, Hu Y, Djukic Z, Tevebaugh W, Shaheen NJ, Orlando RC, Hu J, Chen X. American journal of physiology. Gastrointestinal and liver physiology. 2013 Jul;305:G58-65. [PubMed:23639809] [PMC:PMC3725692] Related Antibodies: LS-B6327.
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ELISA Kits (16)
Cell-Based (1)
Custom (1)
Sandwich (13)
Sandwich CLIA (1)
CLDN1 / Claudin 1 (16)
Human (7)
Mouse (3)
Rat (3)
Bovine (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (12)
No (16)
Adherent Cell Cultures (1)
Cell Lysates (3)
Plasma (8)
Serum (8)
Tissue Homogenates (4)
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CLDN1 / Claudin 1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$893
CLDN1 / Claudin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CLDN1 / Claudin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
CLDN1 / Claudin 1 ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CLDN1 / Claudin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CLDN1 / Claudin 1 ELISA Kit
Select
Custom
96-Well Strip Plate
Bovine
Colorimetric - 450nm (TMB)
1 Plate/$783
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).