CLCF1

cardiotrophin-like cytokine factor 1

CLCF1 is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Proteins (12)

Type

Over-Expression Lysate (4)

Recombinant (8)

Target

CLCF1 (12)

Publications

No (12)

Tag

6His, N-terminus (1)

GST (1)

His (2)

His, N-Terminal (1)

Myc-DDK (Flag) (6)

Species

Human (9)

Mouse (1)

Source

293T Cells (2)

E. coli (5)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Mouse CLCF1 Protein (Recombinant His, N-Terminal) (aa28-225) - LS-G14902

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

26.2 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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Human CLCF1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71028

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25 kDa

Price:

20 µg/$1,107

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Human CLCF1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71029

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.9 kDa

Price:

20 µg/$1,107

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Human CLCF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88591

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25 kDa

Price:

20 µg/$150

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Human CLCF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88592

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.18 kDa

Price:

20 µg/$150

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Human CLCF1 Protein (Recombinant His) (aa88-190) - LS-G14897

Source:

E. coli

Tag:

His

Molecular Weight:

13.1 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human CLCF1 Protein (Recombinant GST) (Full Length) - LS-G32874

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.41 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CLCF1 Protein (Recombinant 6His, N-terminus) (Leu28-Phe225) - LS-G26571

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

24.5 kDa

Price:

10 µg/$265; 50 µg/$315; 200 µg/$484

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CLCF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101113

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25 kDa

Price:

100 µg/$494

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CLCF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128538

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

25.18 kDa

Price:

100 µg/$494

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Human CLCF1 Protein (Recombinant His) - LS-G1399

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human CLCF1 Protein (Recombinant) - LS-G447

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

22.4 kDa

Price:

2 µg/$268; 10 µg/$349

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