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CLCA2

chloride channel accessory 2

CLCA2 belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.

Gene Name: chloride channel accessory 2
Family/Subfamily: Ion Channel , Chloride channel - calcium-activated CLC
Synonyms: CLCA2, Chloride channel accessory 2, CLCRG2, HCaCC-3, HCLCA2, CaCC, CaCC-3, CACC3, Chloride channel regulator 2
Target Sequences: NM_006536 NP_006527.1 Q9UQC9

Publications (1)

1
The Diagnostic and Prognostic Roles of Combined Expression of Novel Biomarkers in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma: An Immunohistochemical Study. Mohamed Ali Alabiad, Ola A Harb, Mohamed Abozaid, Ahmed Embaby, Doaa Mandour, Rehab Hemeda, Amany Mohamed Shalaby. Iranian journal of pathology. 2021 May;16:162-173. [Full Text Article] [PubMed:33936227] [PMC:PMC8085294] Related Antibodies: LS-C664626.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
CLCA2 (4)
No (4)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
CLCA2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CLCA2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
103.94 kDa
20 µg/$150
CLCA2 Protein - Purified recombinant protein CLCA2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
100.6 kDa
20 µg/$1,107
CLCA2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
103.94 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).