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CIT / CRIK / Citron
citron (rho-interacting, serine/threonine kinase 21)
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
| Gene Name: | citron (rho-interacting, serine/threonine kinase 21) |
| Family/Subfamily: | Protein Kinase , DMPK |
| Synonyms: | CIT, Citron, Citron Rho-interacting kinase, Citron-k kinase, KIAA0949, STK21, CRIK |
| Target Sequences: | AB023166 BAA76793.2 O14578 |
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