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CIRP / CIRBP

cold inducible RNA binding protein

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor By similarity. Promotes assembly of stress granules (SGs), when overexpressed.

Gene Name: cold inducible RNA binding protein
Synonyms: CIRBP, A18 hnRNP, A18HNRNP, CIRP
Target Sequences: NM_001280 NP_001271.1 Q14011

Publications (3)

1
Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis. William Royster, Hui Jin, Ping Wang , Monowar Aziz. Molecular medicine (Cambridge, Mass.). 2021 May;27:55. [Full Text Article] [PubMed:34058975] [PMC:PMC8165807]
2
Extracellular CIRP activates STING to exacerbate hemorrhagic shock. Kehong Chen, Joaquin Cagliani, Monowar Aziz, Chuyi Tan, Max Brenner, Ping Wang. JCI insight. 2021 July;6:e143715. [Full Text Article] [PubMed:34291735] [PMC:PMC8410031]
3
Extracellular microRNA 130b-3p inhibits eCIRP-induced inflammation. Steven D Gurien, Monowar Aziz, Hui Jin, Haichao Wang, Mingzhu He, Yousef Al-Abed, Jeffrey M Nicastro, Gene F Coppa, Ping Wang. EMBO reports. 2020 Janurary;21:e48075. [Full Text Article] [PubMed:31724825]

☰ Filters
Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
CIRP / CIRBP (12)
No (12)
6His, N-terminus (1)
GST (2)
GST, N-terminus (2)
His (1)
His, N-Terminal (2)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (9)
Mouse (2)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (4)
CIRP / CIRBP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
22.6 kDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CIRP / CIRBP Protein - Recombinant  Cold Inducible RNA Binding Protein By SDS-PAGE
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E. coli
His-T7
22.5 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
CIRP / CIRBP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
18.5 kDa
100 µg/$494
CIRP / CIRBP Protein - 12.5% SDS-PAGE of human CIRBP stained with Coomassie Blue
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Wheat Germ Extract
GST
44.66 kDa
10 µg/$479; 25 µg/$670
CIRP / CIRBP Protein - 12.5% SDS-PAGE of human CIRBP stained with Coomassie Blue
Select
Wheat Germ Extract
GST
44.66 kDa
2 µg/$439
CIRP / CIRBP Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CIRP / CIRBP Protein - Purified recombinant protein CIRBP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
18.5 kDa
20 µg/$1,107
CIRP / CIRBP Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
18.5 kDa
20 µg/$150
CIRP / CIRBP Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
CIRP / CIRBP Protein - Recombinant Cold Inducible RNA Binding Protein (CIRBP) by SDS-PAGE
Select
E. coli
His, N-Terminal
22/27kDa
10 µg/$285; 50 µg/$467; 200 µg/$932; 100 µg/$745; 1 mg/$2,056; 500 µg/$1,588; 5 mg/$3,256; 2 mg/$2,244
CIRP / CIRBP Protein - Active Cold Inducible RNA Binding Protein (CIRBP) by WB
Select
E. coli
His, N-Terminal
22/27kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).