CHUK / IKKA / IKK Alpha

conserved helix-loop-helix ubiquitous kinase

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

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CHUK / IKKA / IKK Alpha (4)

Publications

No (4)

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GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human CHUK / IKKA / IKK Alpha Protein (Recombinant GST, N-terminus) (aa646-745) - LS-G58138

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CHUK / IKKA / IKK Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80144

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.5 kDa

Price:

20 µg/$215

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CHUK / IKKA / IKK Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99399

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.5 kDa

Price:

100 µg/$710

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Human CHUK / IKKA / IKK Alpha Protein (Recombinant His, N-Terminal) - LS-G145127

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

84.5 kDa

Price:

50 µg/$419

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