CHTOP / FOP

chromatin target of PRMT1

Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CHTOP / FOP (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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CHTOP / FOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113123

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.2 kDa

Price:

100 µg/$494

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Human CHTOP / FOP Protein (Recombinant GST) (Full Length) - LS-G33090

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.8 kDa

Price:

2 µg/$439

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Human CHTOP / FOP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69424

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.2 kDa

Price:

20 µg/$1,107

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Human CHTOP / FOP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84606

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.2 kDa

Price:

20 µg/$150

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