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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CHST7
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.
| Gene Name: | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 |
| Synonyms: | CHST7, C6ST2, GST-5, Gn6st-4, GlcNAc6ST-4, C6ST-2 |
| Target Sequences: | NM_019886 NP_063939.2 Q9NS84 |
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