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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.
| Gene Name: | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 |
| Synonyms: | CHST2, C6ST, GN6ST, Gn6ST-1, GST-2, GST2, GlcNAc6ST-1 |
| Target Sequences: | NM_004267 NP_004258.2 Q9Y4C5 |
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