Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
|Gene Name:||cholinergic receptor, nicotinic, beta 4 (neuronal)|
|Family/Subfamily:||Ion Channel , Nicotinic acetylcholine receptor|
|Synonyms:||CHRNB4, AChR-beta4, NAChR beta 4|
|Target Sequences:||NM_000750 NP_000741.1 P30926|
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