CHRNA7

cholinergic receptor, nicotinic, alpha 7 (neuronal)

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

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Products

ELISA Kits (6)

Type

Custom (2)

Sandwich (4)

Target

CHRNA7 (6)

Reactivity

Human (2)

Mouse (1)

Rat (1)

Bovine (1)

Chicken (1)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (1)

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Human CHRNA7 (Sandwich ELISA) ELISA Kit - LS-F49789

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human CHRNA7 (Sandwich ELISA) ELISA Kit - LS-F8631

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Chicken CHRNA7 (Custom ELISA) ELISA Kit - LS-F49617

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Bovine CHRNA7 (Custom ELISA) ELISA Kit - LS-F49620

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Rat CHRNA7 (Sandwich ELISA) ELISA Kit - LS-F49793

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Mouse CHRNA7 (Sandwich ELISA) ELISA Kit - LS-F49794

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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