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CHRNA3

cholinergic receptor, nicotinic, alpha 3 (neuronal)

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Gene Name: cholinergic receptor, nicotinic, alpha 3 (neuronal)
Family/Subfamily: Ion Channel , Nicotinic acetylcholine receptor
Synonyms: CHRNA3, AChR-alpha3, Acra-3, LNCR2, NAChR alpha 3, PAOD2, NACHRA3
Target Sequences: NM_000743 NP_000734.2 P32297

Publications (1)

1
Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Falvella FS, Galvan A, Frullanti E, Spinola M, Calabr E, Carbone A, Incarbone M, Santambrogio L, Pastorino U, Dragani TA. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:1837-42. (IHC-P; Human) [PubMed:19223495] Related Antibodies: LS-B934.

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Proteins (5)
Recombinant (5)
CHRNA3 (5)
No (5)
10His-SUMO, N-terminus + Myc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His-T7 (1)
Human (5)
E. coli (3)
Wheat Germ Extract (2)
Purified (3)
CHRNA3 Protein - Recombinant Cholinergic Receptor, Nicotinic, Alpha 3 By SDS-PAGE
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E. coli
His-T7
28.3 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
CHRNA3 Protein - 12.5% SDS-PAGE of human CHRNA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
79.42 kDa
2 µg/$439
CHRNA3 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CHRNA3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CHRNA3 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Viewing 1-5 of 5 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).