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CHRM3 / M3

cholinergic receptor, muscarinic 3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.

Gene Name: cholinergic receptor, muscarinic 3
Family/Subfamily: GPCR , Acetylcholine
Synonyms: CHRM3, M3, Muscarinic receptor M3, Muscarinic M3 receptor, EGBRS, HM3, M3 muscarinic receptor
Target Sequences: NM_000740 NP_000731.1 P20309

Publications (1)

1
Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands. Yiyu Wang, Jörg Scheffel, Carolina Ayala Vera, Wei Liu, Dorothee Günzel, Dorothea Terhorst-Molawi, Marcus Maurer, Sabine Altrichter. Frontiers in immunology. 2022 August;13:955161. [Full Text Article] [PubMed:35967390] [PMC:PMC9373796] Related Antibodies: LS-C144026.

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Antibodies (24)
Primary (24)
CHRM3 / M3 (24)
Human (23)
Mouse (6)
Rat (7)
Bat (2)
Bovine (2)
Dog (2)
Guinea pig (1)
Hamster (2)
Horse (2)
Monkey (5)
Pig (2)
Rabbit (2)
Sheep (2)
IHC (11)
IHC-P (8)
WB (12)
Flo (1)
ELISA (17)
Peptide-ELISA (1)
rabbit (22)
mouse (2)
Product Group
GPCR Database Antibodies (5)
IHCPlus (5)
Ig (2)
IgG (12)
IgG1 (1)
IgG2b (1)
monoclonal mc (2)
polyclonal pc (22)
4A6B7 (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (21)
Cytoplasmic Domain (5)
aa253-492 (4)
C-Terminus (3)
aa270-470 (2)
Internal (1)
aa580-589 (1)
No (23)
Yes (1)
CHRM3 / M3 Antibody - Anti-CHRM3 / M3 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
CHRM3 / M3 Antibody - Anti-CHRM3 / M3 antibody IHC of human brain, caudate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
CHRM3 / M3 Antibody - Anti-CHRM3 / M3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
CHRM3 / M3 Antibody - Anti-CHRM3 / M3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
CHRM3 / M3 Antibody - Anti-CHRM3 / M3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
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CHRM3 / M3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$587
CHRM3 / M3 Antibody - Western blot analysis of extracts of mouse brian.
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CHRM3 / M3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CHRM3 / M3 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µg/$896
CHRM3 / M3 Antibody - Western blot analysis using CHRM3 mAb against HEK293 (1) and CHRM3 (AA: extra mix)-hIgGFc transfected HEK293 (2) cell lysate.
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CHRM3 / M3 Mouse anti-Human Monoclonal (4A6B7) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa270-470) Antibody
Human
ELISA
Unconjugated
50 µl/$294; 100 µl/$360
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa580-589) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$828
CHRM3 / M3 Antibody - All lanes: Anti-CHRM3 Antibody (C-Term) at 1:2000 dilution Lane 1: HT-29 whole cell lysate Lane 2: SW620 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 66 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
CHRM3 / M3 Antibody - Immunohistochemistry of paraffin-embedded human heart using antibody at 1:100 dilution.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa270-470) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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CHRM3 / M3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
CHRM3 / M3 Antibody - All lanes: Anti-CHRM3 Antibody (Center) at 1:16000 dilution Lane 1: KG-1 whole cell lysate Lane 2: SW620 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 66 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
CHRM3 / M3 Antibody - Western blot analysis of CHRM3 expression in HEK293 cells. The lane on the left is treated with the antigen-specific peptide.
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CHRM3 / M3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CHRM3 / M3 Antibody - IHC image of CHRM3 Antibody diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa253-492) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa253-492) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa253-492) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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CHRM3 / M3 Rabbit anti-Human Polyclonal (aa253-492) (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
CHRM3 / M3 Antibody - Western blot analysis of extracts of various cell lines, using CHRM3 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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CHRM3 / M3 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CHRM3 / M3 Antibody - Western blot analysis of extracts of various cell lines using CHRM3 Polyclonal Antibody at dilution of 1:3000.
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CHRM3 / M3 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CHRM3 / M3 Antibody - Western blot analysis of extracts of various cell lines using CHRM3 Polyclonal Antibody at dilution of 1:3000.
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CHRM3 / M3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).