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CHRM2 / M2

cholinergic receptor, muscarinic 2

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.

Gene Name: cholinergic receptor, muscarinic 2
Family/Subfamily: GPCR , Acetylcholine
Synonyms: CHRM2, 7TM receptor, HM2, M2 muscarinic receptor, M2-mAChR, Muscarinic receptor M2, Muscarinic M2 receptor
Target Sequences: NM_000739 NP_000730.1 P08172

Publications (1)

1
Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs. Cheng YM, Cao AL, Zheng JP, Wang HW, Sun YS, Liu CF, Zhang BB, Wang Y, Zhu SL, Wu DZ. American journal of respiratory cell and molecular biology. 2014 51:701-8. (WB; Human) [Full Text Article] [PubMed:24828018] Related Antibodies: LS-C124189.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).