CHMP4A

charged multivesicular body protein 4A

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

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Antibodies (6)

Type

Primary (6)

Target

CHMP4A (6)

Reactivity

Human (6)

Pig (3)

Application

WB (6)

Peptide-ELISA (1)

Host

rabbit (5)

mouse (1)

Isotype

IgG (1)

Clonality

polyclonal pc (6)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (3)

Epitope

C-Terminus (4)

aa205-239 (1)

Publications

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CHMP4A Antibody (C-Terminus) LS-C145581

Antibody:

CHMP4A Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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CHMP4A Antibody (C-Terminus, HRP) LS-C469242

Antibody:

CHMP4A Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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CHMP4A Antibody (C-Terminus, Biotin) LS-C469239

Antibody:

CHMP4A Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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CHMP4A Antibody (C-Terminus, FITC) LS-C469240

Antibody:

CHMP4A Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

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  • FITC

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CHMP4A Antibody (aa205-239) LS-C356354

Antibody:

CHMP4A Rabbit anti-Human Polyclonal (aa205-239) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

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CHMP4A Antibody LS-C306949

Antibody:

CHMP4A Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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