CHMP2A

charged multivesicular body protein 2A

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

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ELISA Kits (3)

Type

Custom (2)

Sandwich (1)

Target

CHMP2A (3)

Reactivity

Human (1)

Mouse (1)

Chicken (1)

Format

96-Well Strip Plate (3)

Publications

No (3)

Sample Type

Plasma (1)

Serum (1)

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Chicken CHMP2A (Custom) ELISA Kit - LS-F65585

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Price:

1 Plate/$929

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Mouse CHMP2A (Custom) ELISA Kit - LS-F66160

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Human CHMP2A (Sandwich ELISA) ELISA Kit - LS-F67067

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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