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CHM / REP1

choroideremia (Rab escort protein 1)

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.

Gene Name: choroideremia (Rab escort protein 1)
Synonyms: CHM, Choroideraemia protein, DXS540, GGTA, HSD-32, REP-1, REP1, Rab escort protein 1, TCD, TCD protein
Target Sequences: NM_000390 NP_000381.1 P24386

Publications (1)

1
REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Song KH, Woo SR, Chung JY, Lee HJ, Oh SJ, Hong SO, Shim J, Kim YN, Rho SB, Hong SM, Cho H, Hibi M, Bae DJ, Kim SY, Kim MG, Kim TW, Bae YK. Cell death & disease. 2017 8:e2536. (ICC; Human) [Full Text Article] [PubMed:28055019] [PMC:PMC5386371]

☰ Filters
Antibodies (20)
Proteins (3)
Over-Expression Lysate (2)
Primary (20)
Recombinant (1)
CHM / REP1 (23)
Human (20)
Mouse (2)
Rat (2)
Bovine (1)
Cat (1)
Chicken (1)
Chimpanzee (3)
Dog (1)
Donkey (1)
Goat (1)
Guinea pig (1)
Hamster (1)
Horse (4)
Monkey (1)
Pig (1)
Rabbit (1)
Sheep (1)
IHC (1)
IHC-P (2)
WB (16)
Flo (1)
ELISA (11)
IF (1)
rabbit (19)
goat (1)
Product Group
IHCPlus (1)
IgG (13)
polyclonal pc (20)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (9)
aa292-320 (7)
aa35-84 (4)
aa1-80 (1)
No (23)
6His, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Purified (1)
CHM / REP1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CHM / REP1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CHM / REP1 Antibody - IHC staining of FFPE human thyroid cancer with CHM antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
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CHM / REP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$575
CHM / REP1 Antibody - CHM Antibody western blot of 293 cell line lysates (35 ug/lane). The CHM antibody detected the CHM protein (arrow).
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CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) Antibody
Human
WB
Unconjugated
400 µl/$393
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CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
CHM / REP1 Rabbit anti-Human Polyclonal (aa292-320) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
CHM / REP1 Antibody - Western blot - Anti-CHM antibody
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CHM / REP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
CHM / REP1 Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using CHM Antibody at dilution of 1:100
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CHM / REP1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Select
CHM / REP1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
CHM / REP1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
CHM / REP1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
CHM / REP1 Antibody - CHM antibody Western blot of Fetal Thymus lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHM / REP1 Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
WB
Unconjugated
100 µl/$424
CHM / REP1 Antibody - CHM antibody Western blot of Fetal Thymus lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHM / REP1 Rabbit anti-Human Polyclonal (aa35-84) (HRP) Antibody
Horse, Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
CHM / REP1 Antibody - CHM antibody Western blot of Fetal Thymus lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHM / REP1 Rabbit anti-Human Polyclonal (aa35-84) (Biotin) Antibody
Horse, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
CHM / REP1 Antibody - CHM antibody Western blot of Fetal Thymus lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CHM / REP1 Rabbit anti-Human Polyclonal (aa35-84) (FITC) Antibody
Horse, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
CHM / REP1 Antibody - Western blot analysis of REP-1 expression in H460 (A); HeLa (B) whole cell lysates.
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CHM / REP1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
CHM / REP1 Antibody - Western blot. Anti-REP1 antibody at 1:1000 dilution. HEK293 cells transfected with V5-REP1 and AtT20 cells. Lysates at 100 ug per lane. Rabbit polyclonal to goat IgG (HRP) at 1:10000 dilution.
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CHM / REP1 Goat anti-Rat Polyclonal (aa1-80) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Rat, Hamster, Pig, Cat, Horse, Donkey, Human, Monkey
WB
Unconjugated
600 µg/$409
CHM / REP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
12.1 kDa
100 µg/$494
CHM / REP1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CHM / REP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
12.1 kDa
20 µg/$150
Viewing 1-23 of 23 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).