CHFR

checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

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Products

Proteins (9)

Type

Over-Expression Lysate (6)

Recombinant (3)

Target

CHFR (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CHFR Protein (Recombinant GST, N-terminus) (aa136-194) - LS-G62742

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85865

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.7 kDa

Price:

20 µg/$150

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Human CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85866

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

20 µg/$215

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Human CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85864

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

20 µg/$150

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Human CHFR Protein (Recombinant GST) (Full Length) - LS-G34416

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

97.46 kDa

Price:

10 µg/$479; 25 µg/$670

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CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128303

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

100 µg/$494

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CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128242

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.7 kDa

Price:

100 µg/$494

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Human CHFR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69929

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

20 µg/$1,107

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CHFR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111880

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69 kDa

Price:

100 µg/$710

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