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CHEMR23 / CMKLR1
chemokine-like receptor 1
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
| Gene Name: | chemokine-like receptor 1 |
| Family/Subfamily: | GPCR , Chemoattractant |
| Synonyms: | CMKLR1, Chemokine receptor-like 1, DEZ, CHEMERINR, Resolvin E1 receptor, RVER1, Chemokine-like receptor 1, ChemR23, G-protein coupled receptor DEZ |
| Target Sequences: | NM_004072 NP_004063.1 Q99788 |
Publications (3)
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