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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CHD1

chromodomain helicase DNA binding protein 1

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.

Gene Name: chromodomain helicase DNA binding protein 1
Synonyms: CHD1, ATP-dependent helicase CHD1, CHD-1
Target Sequences: NM_001270 NP_001261.2 O14646

Filtered By: None
Target
CHD1 (15)
Reactivity
Human (15)
Mouse (6)
Rat (1)
Bat (1)
Bovine (2)
Chicken (2)
Chimpanzee (3)
Dog (1)
Gibbon (3)
Horse (6)
Monkey (1)
Pig (1)
Rabbit (5)
Application
IHC (4)
IHC-P (2)
WB (12)
ChrIP (2)
ELISA (4)
ICC (1)
IF (2)
IP (2)
Peptide-ELISA (1)
Host
rabbit (11)
mouse (2)
goat (1)
sheep (1)
Isotype
IgG (8)
IgG1 (1)
IgG2b,k (1)
Clonality
monoclonal mc (2)
polyclonal pc (13)
Clone
11n46 (1)
1G2 (1)
Format
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (12)
Epitope
aa1331-1380 (4)
aa1500-1550 (1)
aa1501-1710 (1)
aa1531-1710 (1)
aa1581-1594 (1)
aa1660-1710 (1)
Publications
No (15)
Showing 1-15 of 15 results

CHD1 Antibody (clone 1G2) IHC-plus™ LS-B12654
Mouse Monoclonal [clone 1G2] (IgG2b,k) to Human CHD1
Human
ELISA IF IHC IHC-P WB
Unconjugated
50µg 0.3mg/ml  $485.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescence of monoclonal antibody to CHD1 on HeLa cell . [antibody concentration 10 ug/ml]
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescence of monoclonal antibody to CHD1 on HeLa cell . [antibody concentration 10 ug/ml]

CHD1 Antibody (aa1501-1710) LS-C375453
Rabbit Polyclonal (IgG) to Human CHD1
Human
ChrIP ELISA IHC IHC-P
Unconjugated
50µl 7.41mg/ml  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.

CHD1 Antibody LS-C664555
Rabbit Polyclonal (IgG) to Human CHD1
Human
ELISA IHC WB
Unconjugated
100µg  $355.00

CHD1 Antibody LS-C409432
Rabbit Polyclonal (IgG) to Human CHD1
Mouse, Rat, Human
IHC WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded mouse brain tissue.
Immunohistochemistry of paraffin-embedded human liver injury tissue.
Immunohistochemistry of paraffin-embedded mouse brain tissue.
Immunohistochemistry of paraffin-embedded human liver injury tissue.

CHD1 Antibody (aa1531-1710, clone 11n46) LS-C184203
Mouse Monoclonal [clone 11n46] (IgG1) to Human CHD1
Human
ICC WB
Unconjugated
100µg 200µl  $620.00

CHD1 Antibody LS-C750010
Rabbit Polyclonal (IgG) to Human CHD1
Human
IF WB
Unconjugated
50µl  $235.00
Immunofluorescence analysis of U2OS cells using CHD1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U2OS cells using CHD1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

CHD1 Antibody (aa1660-1710) LS-C288028
Rabbit Polyclonal (IgG) to Human CHD1
Chicken, Bovine, Rabbit, Dog, Horse, Human
ChrIP IP WB
Unconjugated
100µl 0.2mg/ml  $395.00
ChIP-chip scatter plot of anti-CHD1 enriched DNA binding sites versus input reference DNA. A. 10 ug of was used to immunoprecipitate chromatin from K562 cells according to Ren et al (Genes Dev. 2002 16: 245-256). Immunoprecipitated DNA and reference DNA were amplified via ligation-mediated PCR and the products labeled with fluorescent dUTPs. The labeled ChIP and reference DNA were pooled, hybridized to a DNA microarray, and analyzed. Data points below the +3 SD curve (red line) represent significantly enriched binding sites. B. As a control, a similar experiment was performed using normal rabbit IgG. Compared to the anti-CHD1 ChIP, normal rabbit IgG showed little enrichment.
ChIP-chip scatter plot of anti-CHD1 enriched DNA binding sites versus input reference DNA. A. 10 ug of was used to immunoprecipitate chromatin from K562 cells according to Ren et al (Genes Dev. 2002 16: 245-256). Immunoprecipitated DNA and reference DNA were amplified via ligation-mediated PCR and the products labeled with fluorescent dUTPs. The labeled ChIP and reference DNA were pooled, hybridized to a DNA microarray, and analyzed. Data points below the +3 SD curve (red line) represent significantly enriched binding sites. B. As a control, a similar experiment was performed using normal rabbit IgG. Compared to the anti-CHD1 ChIP, normal rabbit IgG showed little enrichment.

CHD1 Antibody LS-C128078
Sheep Polyclonal (IgG) to Human CHD1
Mouse, Human
ELISA WB
Unconjugated
100µg  $770.00

CHD1 Antibody LS-C347733
Rabbit Polyclonal (IgG) to Human CHD1
Human
WB
Unconjugated
25µg  $345.00

CHD1 Antibody (aa1331-1380) LS-C109901
Rabbit Polyclonal to Human CHD1
Rabbit, Mouse, Horse, Human
WB
Unconjugated
50µg  $365.00
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CHD1 Antibody (aa1331-1380, HRP) LS-C431012
Rabbit Polyclonal to Human CHD1
Rabbit, Mouse, Horse, Gibbon, Human, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CHD1 Antibody (aa1331-1380, Biotin) LS-C431010
Rabbit Polyclonal to Human CHD1
Rabbit, Mouse, Horse, Gibbon, Human, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CHD1 Antibody (aa1331-1380, FITC) LS-C431011
Rabbit Polyclonal to Human CHD1
Rabbit, Mouse, Horse, Gibbon, Human, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
CHD1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CHD1 Antibody (aa1500-1550) LS-C288029
Rabbit Polyclonal (IgG) to Human CHD1
Human
IP
Unconjugated
100µl 1mg/ml  $395.00

CHD1 Antibody (aa1581-1594) LS-C61720
Goat Polyclonal to Human CHD1
Chicken, Bovine, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA
Unconjugated
100µg  $335.00
Showing 1-15 of 15 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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