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Unfortunately, the antibody LS-C190709 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CFTR Antibodies

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), sometimes also referred as ABCC7 (ATP-binding cassette, Subfamily C, Member 7), is a member of the ATP binding cassette (ABC) transporter family. CFTR functions as a chloride channel and controls the regulation of other transport pathways. Homozygous mutations in the CFTR gene cause cystic fibrosis (CF), formerly known as mucoviscidosis, a common hereditary disorder characterized by severe abnormalities in respiratory, digestive and other organ systems. Approximately 70% of the mutations in CF patients correspond to a specific deletion of 3 base pairs, which results in the loss of a phenylalanine at position 508. The approaches aimed to restore the CFTR gene function in CF patients are the subject of intensive research and include the development of gene therapy protocols. In addition to CF syndrome, CFTR mutations were found in patients suffering from bilateral aplasia of the vas deferens (CBAVD). The high frequency of CFTR defects in the human population can be explained by increased resistance to infectious diseases in heterozygous mutation carriers. Alternative splice variants have been described, many of which result from mutations in the CFTR gene.

Gene Name: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: CFTR Antibody, ABC35 Antibody, ABCC7 Antibody, CF Antibody, DJ760C5.1 Antibody, MRP7 Antibody, CFTR/MRP Antibody, TNR-CFTR Antibody
Target Sequences: NM_000492 NP_000483.3 P13569
 CFTR Feature Table

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
CFTR Mouse IgG1 Monoclonal M3A7 Unconjugated Human, Mouse, Rat IHC-P, IF, IP No Primary
Anti-CFTR Antibody (clone M3A7) LS-C87635
IHC Image
Mouse Monoclonal [clone M3A7] (IgG1) to Human CFTR
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Immunoprecipitation
Unconjugated
CFTR Goat Polyclonal Unconjugated Human, Monkey, Bovine, Sheep IHC-P aa2-14 No Primary
Anti-CFTR Antibody (aa2-14) IHC-plus™ LS-B5115
IHC Image
IHC Image
Goat Polyclonal to Human CFTR
Human, Monkey, Bovine, Sheep
IHC - Paraffin
Unconjugated
CFTR Mouse IgM Monoclonal Unconjugated Human, Guinea pig IF, WB, IP aa103-117 No Primary
Anti-CFTR Antibody (aa103-117) LS-C14758
Mouse Monoclonal (IgM) to Human CFTR
Human, Guinea pig
Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC-P, WB Glu733 No Primary
Anti-CFTR Antibody (Glu733) IHC-plus™ LS-B10424
IHC Image
WB Image
Rabbit Polyclonal to Human CFTR
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human, Mouse, Rat IHC-P, IF, WB, ELISA C-Terminus No Primary
Anti-CFTR Antibody (C-Terminus) IHC-plus™ LS-B12049
IHC Image
Rabbit Polyclonal to Human CFTR
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
CFTR Mouse IgG1 Monoclonal L12B4 Unconjugated Human, Mouse, Rat IHC-P, IF, IP No Primary
Anti-CFTR Antibody (clone L12B4) IHC-plus™ LS-B9349
IHC Image
Mouse Monoclonal [clone L12B4] (IgG1) to Human CFTR
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Immunoprecipitation
Unconjugated
CFTR Rabbit IgG Polyclonal Unconjugated Human, Monkey, Mouse, Rat IHC-P, WB aa1463-1480 No Primary
Anti-CFTR Antibody (aa1463-1480) LS-C313304
IHC Image
WB Image
Rabbit Polyclonal (IgG) to Human CFTR
Human, Monkey, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
CFTR Mouse IgG1 Monoclonal M3A7 Unconjugated Human No Primary
Anti-CFTR Antibody (clone M3A7) LS-C95564
IHC Image
Mouse Monoclonal [clone M3A7] (IgG1) to Human CFTR
Human
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human IHC, WB, IP, ELISA C-Terminus No Primary
Anti-CFTR Antibody (C-Terminus) LS-C145001
Rabbit Polyclonal to Human CFTR
Human
IHC, Western blot, Immunoprecipitation, ELISA
Unconjugated
CFTR Mouse IgG1 Monoclonal M3A7 Unconjugated, Azide-free Human, Mouse, Rat IHC-P, IF, IP No Primary
Anti-CFTR Antibody (clone M3A7, Azide-free) LS-C87636
Mouse Monoclonal [clone M3A7] (IgG1) to Human CFTR
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Immunoprecipitation
Unconjugated, Azide-free
CFTR Mouse IgG1 Monoclonal Unconjugated Human IHC, WB, IP, ELISA aa1365-1395 No Primary
Anti-CFTR Antibody (aa1365-1395) LS-C22597
Mouse Monoclonal (IgG1) to Human CFTR
Human
IHC, Western blot, Immunoprecipitation, ELISA
Unconjugated
CFTR Mouse IgG1 Monoclonal GA1 Unconjugated Human WB No Primary
Anti-CFTR Antibody (clone GA1) LS-C179651
WB Image
WB Image
Mouse Monoclonal [clone GA1] (IgG1) to Human CFTR
Human
Western blot
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human WB Glu865 No Primary
Anti-CFTR Antibody (Glu865) LS-C177383
WB Image
Rabbit Polyclonal to Human CFTR
Human
Western blot
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human IF, WB, IP, ELISA C-Terminus No Primary
Anti-CFTR Antibody (C-Terminus) LS-C153425
Rabbit Polyclonal to Human CFTR
Human
Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated
CFTR Mouse IgG1 Monoclonal Unconjugated Human, Horse, Pig, Rabbit ICC, WB, IP aa25-36 No Primary
Anti-CFTR Antibody (aa25-36) LS-C152933
Mouse Monoclonal (IgG1) to Human CFTR
Human, Horse, Pig, Rabbit
ICC, Western blot, Immunoprecipitation
Unconjugated
CFTR Mouse IgG1 Monoclonal L12B4 Unconjugated, Azide-free Human, Mouse, Rat IF, IP No Primary
Anti-CFTR Antibody (clone L12B4, Azide-free) LS-C87634
Mouse Monoclonal [clone L12B4] (IgG1) to Human CFTR
Human, Mouse, Rat
Immunofluorescence, Immunoprecipitation
Unconjugated, Azide-free
CFTR Rabbit Polyclonal Unconjugated Human, Sheep WB, ELISA C-Terminus No Primary
Anti-CFTR Antibody (C-Terminus) LS-C46927
Rabbit Polyclonal to Human CFTR
Human, Sheep
Western blot, ELISA
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human No Primary
Anti-CFTR Antibody LS-C86981
Rabbit Polyclonal to Human CFTR
Human
Unconjugated
CFTR Mouse IgG1,k Monoclonal Unconjugated Human, Horse, Pig, Rabbit ICC, IF, WB, IP, ELISA aa25-36 No Primary
Anti-CFTR Antibody (aa25-36) LS-C22596
Mouse Monoclonal (IgG1,k) to Human CFTR
Human, Horse, Pig, Rabbit
ICC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated
CFTR Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Rat WB, ELISA N-Terminus No Primary
Anti-CFTR Antibody (N-Terminus) LS-C36072
Rabbit Polyclonal to Human CFTR
Human, Monkey, Mouse, Rat
Western blot, ELISA
Unconjugated
CFTR Rabbit IgG Polyclonal Unconjugated Human, Guinea pig ICC aa103-117 No Primary
Anti-CFTR Antibody (aa103-117) LS-C14756
Rabbit Polyclonal (IgG) to Human CFTR
Human, Guinea pig
ICC
Unconjugated
Target Corresponding Antibodies
CFTR
CFTR Antibody Blocking Peptide - LS-E25852
LS-E25852
CFTR
LS-B5115
Type Target Reactivity Sample Type
Sandwich CFTR Human Cell Lysates, Tissue Homogenates
Human CFTR ELISA Kit - LS-F6347
Sandwich
Human
96-Well Strip Plate with Colorimetric - 450nm detection type
Cell Lysates, Tissue Homogenates

CFTR Feature Table


Feature Type Location Details
alternative products 1 - 1480 Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P13569-1; Sequence=Displayed; Name=2; IsoId=P13569-2; Sequence=VSP_022123; Note=Skipping of exon 9: a high number of TG repeats and a low number of T repeats at the intron 8-exon 9 junction favor exon skipping. Causes congenital bilateral absence of the vas deferens (CBAVD); Name=3; IsoId=P13569-3; Sequence=VSP_022124, VSP_022125; Note=Skipping of the first 248 nucleotides of exon 13, caused by mutation of the exon splicing exon (ESE) in exon 13. Causes cystic fibrosis (CF);
catalytic activity 1 - 1480 ATP + H(2)O = ADP + phosphate.
Disease 1 - 1480 Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD) [MIM:277180]. CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Disease 1 - 1480 Defects in CFTR are the cause of cystic fibrosis (CF) [MIM:219700]; also known as mucoviscidosis. CF is the most common genetic disease in the Caucasian population, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive. CF is a common generalized disorder of exocrine gland function which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes.
domain 1 - 1480 The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
Function 1 - 1480 Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
interaction 1 - 1480 P51572:BCAP31; NbExp=2; IntAct=EBI-349854, EBI-77683; Q9BUN8:DERL1; NbExp=1; IntAct=EBI-349854, EBI-398977; Q9HD26:GOPC; NbExp=1; IntAct=EBI-349854, EBI-349832; Q9HBW0:LPAR2; NbExp=1; IntAct=EBI-349854, EBI-765995; Q5T2W1:PDZK1; NbExp=1; IntAct=EBI-349854, EBI-349819; Q99942:RNF5; NbExp=1; IntAct=EBI-349854, EBI-348482; O14745:SLC9A3R1; NbExp=1; IntAct=EBI-349854, EBI-349787; Q15599:SLC9A3R2; NbExp=1; IntAct=EBI-349854, EBI-1149760;
ptm 1 - 1480 Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites.
ptm 1 - 1480 Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling.
Similarity 1 - 1480 Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Similarity 1 - 1480 Contains 2 ABC transmembrane type-1 domains.
Similarity 1 - 1480 Contains 2 ABC transporter domains.
Subcellular Location 1 - 1480 Early endosome membrane; Multi-pass membrane protein.
Subunit 1 - 1480 Interacts with SHANK2 (By similarity). Interacts with SLC9A3R1, MYO6 and GOPC. Interacts with SLC4A7 through SLC9A3R1.
Tissue Specificity 1 - 1480 Found on the surface of the epithelial cells that line the lungs and other organs.
web resource 1 - 1480 Name=CFTR; Note=Cystic fibrosis mutation db; URL="http://www.genet.sickkids.on.ca/cftr/app";
web resource 1 - 1480 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CFTR";
web resource 1 - 1480 Name=Wikipedia; Note=CFTR entry; URL="http://en.wikipedia.org/wiki/Cystic_fibrosis_transmembrane_conductance_regulator";
arrayexpress 1 - 1480 P13569
bgee 1 - 1480 P13569
brenda 1 - 1480 3.6.3.49
cleanex 1 - 1480 HS_CFTR
ctd 1 - 1480 1080
dip 1 - 1480 DIP-29617N
dip 1 - 1480 DIP-32788N
disprot 1 - 1480 DP00012
doi 1 - 1480 10
drugbank 1 - 1480 DB00887
drugbank 1 - 1480 DB01016
eggnog 1 - 1480 prNOG15545
embl 1 - 1480 AC000061
embl 1 - 1480 AC000111
embl 1 - 1480 CH236947
embl 1 - 1480 DQ354388
embl 1 - 1480 DQ354389
embl 1 - 1480 DQ354390
embl 1 - 1480 DQ354391
embl 1 - 1480 DQ356258
embl 1 - 1480 DQ356259
embl 1 - 1480 DQ356261
embl 1 - 1480 DQ356262
embl 1 - 1480 DQ356263
embl 1 - 1480 DQ356264
embl 1 - 1480 DQ388128
embl 1 - 1480 DQ388129
embl 1 - 1480 DQ388131
embl 1 - 1480 DQ388132
embl 1 - 1480 DQ388133
embl 1 - 1480 DQ388134
embl 1 - 1480 DQ388135
embl 1 - 1480 DQ388138
embl 1 - 1480 DQ388139
embl 1 - 1480 DQ388140
embl 1 - 1480 DQ388141
embl 1 - 1480 DQ388142
embl 1 - 1480 DQ388143
embl 1 - 1480 DQ388145
embl 1 - 1480 M28668
embl 1 - 1480 M55106
embl 1 - 1480 M55107
embl 1 - 1480 M55108
embl 1 - 1480 M55110
embl 1 - 1480 M55111
embl 1 - 1480 M55112
embl 1 - 1480 M55113
embl 1 - 1480 M55114
embl 1 - 1480 M55115
embl 1 - 1480 M55116
embl 1 - 1480 M55117
embl 1 - 1480 M55118
embl 1 - 1480 M55119
embl 1 - 1480 M55120
embl 1 - 1480 M55121
embl 1 - 1480 M55122
embl 1 - 1480 M55123
embl 1 - 1480 M55124
embl 1 - 1480 M55125
embl 1 - 1480 M55126
embl 1 - 1480 M55127
embl 1 - 1480 M55128
embl 1 - 1480 M55129
embl 1 - 1480 M55130
embl 1 - 1480 M55131
embl 1 - 1480 M65196
embl 1 - 1480 M65197
ensembl 1 - 1480 ENST00000003084
genecards 1 - 1480 GC07P117119
geneid 1 - 1480 1080
genevestigator 1 - 1480 P13569
go 1 - 1480 GO:0005224
go 1 - 1480 GO:0005260
go 1 - 1480 GO:0005524
go 1 - 1480 GO:0007585
go 1 - 1480 GO:0016323
go 1 - 1480 GO:0016324
go 1 - 1480 GO:0019899
go 1 - 1480 GO:0030165
go 1 - 1480 GO:0031901
go 1 - 1480 GO:0034707
hgnc 1 - 1480 HGNC:1884
hogenom 1 - 1480 HBG444760
hovergen 1 - 1480 HBG004169
hpa 1 - 1480 CAB001951
hpa 1 - 1480 HPA021939
inparanoid 1 - 1480 P13569
intact 1 - 1480 P13569
interpro 1 - 1480 IPR001140
interpro 1 - 1480 IPR003439
interpro 1 - 1480 IPR003593
interpro 1 - 1480 IPR005291
interpro 1 - 1480 IPR009147
interpro 1 - 1480 IPR011527
interpro 1 - 1480 IPR017871
interpro 1 - 1480 IPR017940
ipi 1 - 1480 IPI00815998
ipi 1 - 1480 IPI00816721
ipi 1 - 1480 IPI00816790
kegg 1 - 1480 hsa:1080
medline 1 - 1480 21283011
medline 1 - 1480 21671338
medline 1 - 1480 22616434
medline 1 - 1480 22737999
medline 1 - 1480 89368940
medline 1 - 1480 90326187
medline 1 - 1480 91046014
medline 1 - 1480 91257831
medline 1 - 1480 91257839
medline 1 - 1480 92316961
medline 1 - 1480 92339790
medline 1 - 1480 93190992
medline 1 - 1480 93244747
medline 1 - 1480 93244771
medline 1 - 1480 93250787
medline 1 - 1480 93250788
medline 1 - 1480 93250808
medline 1 - 1480 93252404
medline 1 - 1480 93258355
medline 1 - 1480 94080255
medline 1 - 1480 94093573
medline 1 - 1480 94222417
medline 1 - 1480 94290492
medline 1 - 1480 94333927
medline 1 - 1480 94362712
medline 1 - 1480 94375072
medline 1 - 1480 95038714
medline 1 - 1480 95038762
medline 1 - 1480 95048290
medline 1 - 1480 95126122
medline 1 - 1480 95245339
medline 1 - 1480 95285566
medline 1 - 1480 95322977
medline 1 - 1480 95327091
medline 1 - 1480 95363605
medline 1 - 1480 95377736
medline 1 - 1480 96047156
medline 1 - 1480 96101900
medline 1 - 1480 96233933
medline 1 - 1480 96254901
medline 1 - 1480 96303714
medline 1 - 1480 96303716
medline 1 - 1480 97114290
medline 1 - 1480 97220599
medline 1 - 1480 97255970
medline 1 - 1480 97365941
medline 1 - 1480 98041703
medline 1 - 1480 98046756
medline 1 - 1480 98062178
medline 1 - 1480 98107952
medline 1 - 1480 98112427
medline 1 - 1480 98112433
medline 1 - 1480 98112452
medline 1 - 1480 98141683
medline 1 - 1480 98176720
medline 1 - 1480 98180894
medline 1 - 1480 98213475
medline 1 - 1480 98409505
medline 1 - 1480 99118882
medline 1 - 1480 99140272
mim 1 - 1480 219700
mim 1 - 1480 277180
mim 1 - 1480 602421
mint 1 - 1480 MINT-148539
nextbio 1 - 1480 4500
nmpdr 1 - 1480 fig|9606.3.peg.29332
oma 1 - 1480 GMQMRIA
orphanet 1 - 1480 48
orphanet 1 - 1480 586
orphanet 1 - 1480 676
orthodb 1 - 1480 EOG91VNN9
panther 1 - 1480 PTHR19242:SF8
pdb 1 - 1480 1NBD
pdb 1 - 1480 1XMI
pdb 1 - 1480 1XMJ
pdb 1 - 1480 2BBO
pdb 1 - 1480 2BBS
pdb 1 - 1480 2BBT
pdb 1 - 1480 2PZE
pdb 1 - 1480 2PZF
pdb 1 - 1480 2PZG
pdb 1 - 1480 3GD7
pdb 1 - 1480 3ISW
pdbsum 1 - 1480 1NBD
pdbsum 1 - 1480 1XMI
pdbsum 1 - 1480 1XMJ
pdbsum 1 - 1480 2BBO
pdbsum 1 - 1480 2BBS
pdbsum 1 - 1480 2BBT
pdbsum 1 - 1480 2PZE
pdbsum 1 - 1480 2PZF
pdbsum 1 - 1480 2PZG
pdbsum 1 - 1480 3GD7
pdbsum 1 - 1480 3ISW
pfam 1 - 1480 PF00005
pfam 1 - 1480 PF00664
pharmgkb 1 - 1480 PA109
phosphosite 1 - 1480 P13569
phylomedb 1 - 1480 P13569
pir 1 - 1480 A39069
pride 1 - 1480 P13569
prints 1 - 1480 PR01851
prosite 1 - 1480 PS00211
prosite 1 - 1480 PS50893
prosite 1 - 1480 PS50929
proteinmodelportal 1 - 1480 P13569
pubmed 1 - 1480 10094564
pubmed 1 - 1480 10651488
pubmed 1 - 1480 10766763
pubmed 1 - 1480 11304524
pubmed 1 - 1480 11707463
pubmed 1 - 1480 12403779
pubmed 1 - 1480 12588899
pubmed 1 - 1480 12690205
pubmed 1 - 1480 1284466
pubmed 1 - 1480 1284468
pubmed 1 - 1480 1284529
pubmed 1 - 1480 1284530
pubmed 1 - 1480 1284534
pubmed 1 - 1480 12853948
pubmed 1 - 1480 12913074
pubmed 1 - 1480 1377674
pubmed 1 - 1480 1378801
pubmed 1 - 1480 15247260
pubmed 1 - 1480 1695717
pubmed 1 - 1480 17053785
pubmed 1 - 1480 1710598
pubmed 1 - 1480 1710600
pubmed 1 - 1480 18987736
pubmed 1 - 1480 19398555
pubmed 1 - 1480 19413330
pubmed 1 - 1480 2236053
pubmed 1 - 1480 2475911
pubmed 1 - 1480 7504969
pubmed 1 - 1480 7505694
pubmed 1 - 1480 7513296
pubmed 1 - 1480 7517264
pubmed 1 - 1480 7518437
pubmed 1 - 1480 7520022
pubmed 1 - 1480 7522211
pubmed 1 - 1480 7524909
pubmed 1 - 1480 7524913
pubmed 1 - 1480 7525450
pubmed 1 - 1480 7529962
pubmed 1 - 1480 7537150
pubmed 1 - 1480 7539342
pubmed 1 - 1480 7541273
pubmed 1 - 1480 7541510
pubmed 1 - 1480 7543567
pubmed 1 - 1480 7544319
pubmed 1 - 1480 7581407
pubmed 1 - 1480 7680525
pubmed 1 - 1480 7683628
pubmed 1 - 1480 7683954
pubmed 1 - 1480 8081395
pubmed 1 - 1480 8522333
pubmed 1 - 1480 8723693
pubmed 1 - 1480 8723695
pubmed 1 - 1480 8800923
pubmed 1 - 1480 8829633
pubmed 1 - 1480 8956039
pubmed 1 - 1480 9067761
pubmed 1 - 1480 9101301
pubmed 1 - 1480 9222768
pubmed 1 - 1480 9375855
pubmed 1 - 1480 9385646
pubmed 1 - 1480 9401006
pubmed 1 - 1480 9443874
pubmed 1 - 1480 9452048
pubmed 1 - 1480 9452054
pubmed 1 - 1480 9452073
pubmed 1 - 1480 9482579
pubmed 1 - 1480 9517543
pubmed 1 - 1480 9521595
pubmed 1 - 1480 9554753
pubmed 1 - 1480 9736778
pubmed 1 - 1480 9921909
reactome 1 - 1480 REACT_15518
refseq 1 - 1480 NP_000483.3
smart 1 - 1480 SM00382
smr 1 - 1480 P13569
string 1 - 1480 P13569
supfam 1 - 1480 SSF90123
tcdb 1 - 1480 3.A.1.202.1
tigrfams 1 - 1480 TIGR01271
ucsc 1 - 1480 uc003vjd.1
unigene 1 - 1480 Hs.489786
unigene 1 - 1480 Hs.621460
unigene 1 - 1480 Hs.661104
joined; genomic_dna 1 - 1480 AAC13657.1
not_annotated_cds; genomic_dna 1 - 1480 -
carbohyd 894 - 894 N-linked (GlcNAc...)
carbohyd 900 - 900 N-linked (GlcNAc...)
chain 1 - 1480 Cystic fibrosis transmembrane conductance regulator. /FTId=PRO_0000093419.
conflict 620 - 620 H -> N (in Ref. 1; AAA35680)
conflict 833 - 833 F -> L (in Ref. 1; AAA35680)
domain 81 - 365 ABC transmembrane type-1 1
domain 423 - 646 ABC transporter 1
domain 859 - 1155 ABC transmembrane type-1 2
domain 1210 - 1443 ABC transporter 2
Modification 515 - 515 Phosphotyrosine
Modification 660 - 660 Phosphoserine; by PKA
Modification 686 - 686 Phosphoserine; by PKC
Modification 700 - 700 Phosphoserine; by PKA
Modification 712 - 712 Phosphoserine; by PKA
Modification 737 - 737 Phosphoserine; by PKA
Modification 753 - 753 Phosphoserine; by PKA
Modification 768 - 768 Phosphoserine; by PKA
Modification 790 - 790 Phosphoserine; by PKC
Modification 795 - 795 Phosphoserine; by PKA
Modification 813 - 813 Phosphoserine; by PKA
Modification 1176 - 1176 Phosphothreonine
motif 1478 - 1480 PDZ-binding
np_bind 458 - 465 ATP 1 (Potential)
np_bind 1244 - 1251 ATP 2 (Potential)
topo_dom 1 - 80 Cytoplasmic (Potential)
topo_dom 104 - 117 Extracellular (Potential)
topo_dom 139 - 194 Cytoplasmic (Potential)
topo_dom 216 - 220 Extracellular (Potential)
topo_dom 242 - 307 Cytoplasmic (Potential)
topo_dom 329 - 330 Extracellular (Potential)
topo_dom 351 - 859 Cytoplasmic (Potential)
topo_dom 881 - 911 Extracellular (Potential)
topo_dom 933 - 990 Cytoplasmic (Potential)
topo_dom 1012 - 1013 Extracellular (Potential)
topo_dom 1035 - 1102 Cytoplasmic (Potential)
topo_dom 1124 - 1128 Extracellular (Potential)
topo_dom 1150 - 1480 Cytoplasmic (Potential)
transmem 81 - 103 Helical; Name=1; (Potential)
transmem 118 - 138 Helical; Name=2; (Potential)
transmem 195 - 215 Helical; Name=3; (Potential)
transmem 221 - 241 Helical; Name=4; (Potential)
transmem 308 - 328 Helical; Name=5; (Potential)
transmem 331 - 350 Helical; Name=6; (Potential)
transmem 860 - 880 Helical; Name=7; (Potential)
transmem 912 - 932 Helical; Name=8; (Potential)
transmem 991 - 1011 Helical; Name=9; (Potential)
transmem 1014 - 1034 Helical; Name=10; (Potential)
transmem 1103 - 1123 Helical; Name=11; (Potential)
transmem 1129 - 1149 Helical; Name=12; (Potential)
var_seq 404 - 464 Missing (in isoform 2) /FTId=VSP_022123.
var_seq 589 - 605 SCVCKLMANKTRILVTS -> RRRCSCLLDRNKKTIF (in isoform 3). /FTId=VSP_022124.
var_seq 606 - 1480 Missing (in isoform 3) /FTId=VSP_022125.
variant 13 - 13 S -> F (in CF) /FTId=VAR_000101.
variant 31 - 31 R -> C (in dbSNP:rs1800073) /FTId=VAR_000102.
variant 31 - 31 R -> L (in CF) /FTId=VAR_000103.
variant 42 - 42 S -> F (in CF) /FTId=VAR_000104.
variant 44 - 44 D -> G (in CF) /FTId=VAR_000105.
variant 44 - 44 D -> V (in dbSNP:rs1800074) /FTId=VAR_000106.
variant 50 - 50 S -> Y (in CBAVD) /FTId=VAR_000107.
variant 57 - 57 W -> G (in CF) /FTId=VAR_000108.
variant 67 - 67 P -> L (in CF) /FTId=VAR_000109.
variant 74 - 74 R -> W (in CF) /FTId=VAR_000110.
variant 75 - 75 R -> Q (in dbSNP:rs1800076) /FTId=VAR_000111.
variant 85 - 85 G -> E (in CF) /FTId=VAR_000112.
variant 87 - 87 F -> L (in CF) /FTId=VAR_000113.
variant 91 - 91 G -> R (in CF) /FTId=VAR_000114.
variant 92 - 92 E -> K (in CF) /FTId=VAR_000115.
variant 98 - 98 Q -> R (in CF) /FTId=VAR_000116.
variant 105 - 105 I -> S (in CF) /FTId=VAR_000117.
variant 109 - 109 Y -> C (in CF) /FTId=VAR_000118.
variant 110 - 110 D -> H (in CF) /FTId=VAR_000119.
variant 111 - 111 P -> L (in CBAVD) /FTId=VAR_000120.
variant 117 - 117 R -> C (in CF) /FTId=VAR_000121.
variant 117 - 117 R -> H (in CF and CBAVD) /FTId=VAR_000122.
variant 117 - 117 R -> L (in CF) /FTId=VAR_000123.
variant 117 - 117 R -> P (in CF) /FTId=VAR_000124.
variant 120 - 120 A -> T (in CF) /FTId=VAR_000125.
variant 138 - 138 L -> P (in dbSNP:rs1800078) /FTId=VAR_009895.
variant 139 - 139 H -> R (in CF) /FTId=VAR_000126.
variant 141 - 141 A -> D (in CF) /FTId=VAR_000127.
variant 148 - 148 I -> T (in CF; dbSNP:rs35516286) /FTId=VAR_000128.
variant 149 - 149 G -> R (in CBAVD) /FTId=VAR_000129.
variant 170 - 170 R -> H (in dbSNP:rs1800079) /FTId=VAR_009896.
variant 178 - 178 G -> R (in CF) /FTId=VAR_000130.
variant 182 - 182 S -> G (in dbSNP:rs1800080) /FTId=VAR_009897.
variant 192 - 192 Missing (in CF) /FTId=VAR_000131.
variant 193 - 193 E -> K (in CBAVD and CF) /FTId=VAR_000132.
variant 199 - 199 H -> Q (in CF) /FTId=VAR_000133.
variant 199 - 199 H -> Y (in CF) /FTId=VAR_000134.
variant 205 - 205 P -> S (in CF) /FTId=VAR_000135.
variant 206 - 206 L -> W (in CF) /FTId=VAR_000136.
variant 225 - 225 C -> R (in CF) /FTId=VAR_000137.
variant 244 - 244 M -> K (in CBAVD) /FTId=VAR_000138.
variant 258 - 258 R -> G (in CBAVD) /FTId=VAR_000139.
variant 287 - 287 N -> Y (in CF) /FTId=VAR_000140.
variant 297 - 297 R -> Q (in CF) /FTId=VAR_000141.
variant 301 - 301 Y -> C (in CF) /FTId=VAR_000142.
variant 307 - 307 S -> N (in CF) /FTId=VAR_000143.
variant 311 - 311 F -> L (in CF) /FTId=VAR_000144.
variant 311 - 311 Missing (in CF) /FTId=VAR_000145.
variant 314 - 314 G -> E (in CF) /FTId=VAR_000146.
variant 314 - 314 G -> R (in CF) /FTId=VAR_000147.
variant 322 - 322 V -> M (in dbSNP:rs1800085) /FTId=VAR_009898.
variant 334 - 334 R -> W (in CF; mild) /FTId=VAR_000148.
variant 336 - 336 I -> K (in CF) /FTId=VAR_000150.
variant 338 - 338 T -> I (in CF; mild; isolated hypotonic dehydration). /FTId=VAR_000151.
variant 346 - 346 L -> P (in CF; dominant mutation but mild phenotype). /FTId=VAR_000152.
variant 347 - 347 R -> H (in CF) /FTId=VAR_000153.
variant 347 - 347 R -> L (in CF) /FTId=VAR_000154.
variant 347 - 347 R -> P (in CF; MILD) /FTId=VAR_000155.
variant 351 - 351 T -> S (in dbSNP:rs1800086) /FTId=VAR_009899.
variant 352 - 352 R -> Q (in CF) /FTId=VAR_000156.
variant 353 - 353 Q -> H (in dbSNP:rs1800087) /FTId=VAR_009900.
variant 359 - 359 Q -> K (in CF) /FTId=VAR_000157.
variant 359 - 360 QT -> KK (in CF) /FTId=VAR_000158.
variant 370 - 370 K -> KNK (in CF) /FTId=VAR_000159.
variant 455 - 455 A -> E (in CF) /FTId=VAR_000160.
variant 456 - 456 V -> F (in CF) /FTId=VAR_000161.
variant 458 - 458 G -> V (in CF) /FTId=VAR_000162.
variant 467 - 467 L -> F (in dbSNP:rs1800089) /FTId=VAR_000163.
variant 470 - 470 V -> M (in dbSNP:rs213950) /FTId=VAR_000164.
variant 480 - 480 G -> C (in CF) /FTId=VAR_000165.
variant 492 - 492 S -> F (in CF) /FTId=VAR_000166.
variant 504 - 504 E -> Q (in CF) /FTId=VAR_000167.
variant 506 - 506 I -> M (in dbSNP:rs1800092) /FTId=VAR_009901.
variant 506 - 506 I -> V /FTId=VAR_000168.
variant 507 - 507 I -> V (in dbSNP:rs1800091) /FTId=VAR_000169.
variant 507 - 507 Missing (in CF) /FTId=VAR_000170.
variant 508 - 508 F -> C (in dbSNP:rs1800093) /FTId=VAR_000172.
variant 508 - 508 Missing (in CF and CBAVD; most common mutation; 72% of the population; CFTR fails to be properly delivered to plasma membrane). /FTId=VAR_000171.
variant 513 - 513 D -> G (in CBAVD) /FTId=VAR_000173.
variant 520 - 520 V -> F (in CF) /FTId=VAR_000174.
variant 532 - 532 K -> E (in dbSNP:rs35032490) /FTId=VAR_048150.
variant 544 - 544 G -> V (in CBAVD) /FTId=VAR_000175.
variant 549 - 549 S -> I (in CF) /FTId=VAR_000177.
variant 549 - 549 S -> N (in CF) /FTId=VAR_000176.
variant 549 - 549 S -> R (in CF) /FTId=VAR_000178.
variant 551 - 551 G -> D (in CF) /FTId=VAR_000179.
variant 551 - 551 G -> S (in CF) /FTId=VAR_000180.
variant 553 - 553 R -> Q (in CF) /FTId=VAR_000181.
variant 558 - 558 L -> S (in CF) /FTId=VAR_000182.
variant 559 - 559 A -> T (in CF) /FTId=VAR_000183.
variant 560 - 560 R -> K (in CF) /FTId=VAR_000184.
variant 560 - 560 R -> S (in CF) /FTId=VAR_000185.
variant 560 - 560 R -> T (in CF) /FTId=VAR_000186.
variant 562 - 562 V -> I (in dbSNP:rs1800097) /FTId=VAR_000187.
variant 562 - 562 V -> L (in CF) /FTId=VAR_000188.
variant 563 - 563 Y -> N (in CF) /FTId=VAR_000189.
variant 569 - 569 Y -> C (in CF) /FTId=VAR_000190.
variant 569 - 569 Y -> D (in CF) /FTId=VAR_000191.
variant 569 - 569 Y -> H (in CF) /FTId=VAR_000192.
variant 571 - 571 L -> S (in CF) /FTId=VAR_000193.
variant 572 - 572 D -> N (in CF) /FTId=VAR_000194.
variant 574 - 574 P -> H (in CF) /FTId=VAR_000195.
variant 576 - 576 G -> A (in dbSNP:rs1800098) /FTId=VAR_000196.
variant 579 - 579 D -> G (in CF) /FTId=VAR_000197.
variant 601 - 601 I -> F (in CF) /FTId=VAR_000198.
variant 605 - 605 S -> F (in dbSNP:rs766874) /FTId=VAR_048151.
variant 610 - 610 L -> S (in CF) /FTId=VAR_000199.
variant 613 - 613 A -> T (in CF) /FTId=VAR_000200.
variant 614 - 614 D -> G (in CF) /FTId=VAR_000201.
variant 618 - 618 I -> T (in CF) /FTId=VAR_000202.
variant 619 - 619 L -> S (in CF) /FTId=VAR_000203.
variant 620 - 620 H -> P (in CF) /FTId=VAR_000204.
variant 620 - 620 H -> Q (in CF) /FTId=VAR_000205.
variant 622 - 622 G -> D (in oligospermia) /FTId=VAR_000206.
variant 628 - 628 G -> R (in CF) /FTId=VAR_000207.
variant 633 - 633 L -> P (in CF) /FTId=VAR_000208.
variant 648 - 648 D -> V (in CF) /FTId=VAR_000209.
variant 651 - 651 D -> N (in CF) /FTId=VAR_000210.
variant 654 - 654 S -> G (in dbSNP:rs1800099) /FTId=VAR_009902.
variant 665 - 665 T -> S (in CF) /FTId=VAR_000211.
variant 668 - 668 R -> C (in dbSNP:rs1800100) /FTId=VAR_000212.
variant 693 - 693 F -> L (in dbSNP:rs1800101) /FTId=VAR_000213.
variant 754 - 754 V -> M (in CF) /FTId=VAR_000214.
variant 766 - 766 R -> M (in CBAVD) /FTId=VAR_000215.
variant 792 - 792 R -> G (in CBAVD) /FTId=VAR_000216.
variant 800 - 800 A -> G (in CBAVD) /FTId=VAR_000217.
variant 807 - 807 I -> M (in CBAVD; dbSNP:rs1800103) /FTId=VAR_000218.
variant 822 - 822 E -> K (in CF) /FTId=VAR_000219.
variant 826 - 826 E -> K (in thoracic sarcoidosis) /FTId=VAR_000220.
variant 866 - 866 C -> Y (in CF) /FTId=VAR_000221.
variant 903 - 903 Y -> H (in dbSNP:rs1800106) /FTId=VAR_009903.
variant 909 - 909 S -> I (in dbSNP:rs1800107) /FTId=VAR_009904.
variant 912 - 912 S -> L /FTId=VAR_000222.
variant 913 - 913 Y -> C (in CF) /FTId=VAR_000223.
variant 917 - 917 Y -> C (in CF) /FTId=VAR_000224.
variant 949 - 949 H -> Y (in CF) /FTId=VAR_000225.
variant 952 - 952 M -> I (in CF) /FTId=VAR_000226.
variant 967 - 967 L -> S (in dbSNP:rs1800110) /FTId=VAR_009905.
variant 997 - 997 L -> F (in CF; dbSNP:rs1800111) /FTId=VAR_000227.
variant 1005 - 1005 I -> R (in CF) /FTId=VAR_000228.
variant 1006 - 1006 A -> E (in CF) /FTId=VAR_000229.
variant 1013 - 1013 P -> L (in CF) /FTId=VAR_000230.
variant 1028 - 1028 M -> I (in CF) /FTId=VAR_000231.
variant 1052 - 1052 F -> V (in CF) /FTId=VAR_000232.
variant 1061 - 1061 G -> R (in CF) /FTId=VAR_000233.
variant 1065 - 1065 L -> P (in CF) /FTId=VAR_000234.
variant 1065 - 1065 L -> R (in CF) /FTId=VAR_000235.
variant 1066 - 1066 R -> C (in CF) /FTId=VAR_000236.
variant 1066 - 1066 R -> H (in CF) /FTId=VAR_000237.
variant 1066 - 1066 R -> L (in CF) /FTId=VAR_000238.
variant 1067 - 1067 A -> T (in CF) /FTId=VAR_000239.
variant 1067 - 1067 A -> V (in dbSNP:rs1800114) /FTId=VAR_000240.
variant 1070 - 1070 R -> P (in CF) /FTId=VAR_000242.
variant 1070 - 1070 R -> Q (in CF) /FTId=VAR_000241.
variant 1070 - 1070 R -> W (in CBAVD) /FTId=VAR_011564.
variant 1071 - 1071 Q -> P (in CF) /FTId=VAR_000243.
variant 1072 - 1072 P -> L (in CF) /FTId=VAR_000244.
variant 1077 - 1077 L -> P (in CF) /FTId=VAR_000245.
variant 1085 - 1085 H -> R (in CF) /FTId=VAR_000246.
variant 1098 - 1098 W -> R (in CF) /FTId=VAR_000247.
variant 1101 - 1101 M -> K (in CF; dbSNP:rs36210737) /FTId=VAR_000248.
variant 1101 - 1101 M -> R (in CF) /FTId=VAR_011565.
variant 1137 - 1137 M -> V (in CF) /FTId=VAR_000249.
variant 1140 - 1140 Missing (in CF) /FTId=VAR_000250.
variant 1152 - 1152 D -> H (in CF) /FTId=VAR_000251.
variant 1162 - 1162 R -> L (in dbSNP:rs1800120) /FTId=VAR_000252.
variant 1220 - 1220 T -> I (in dbSNP:rs1800123) /FTId=VAR_000253.
variant 1234 - 1234 I -> V (in CF) /FTId=VAR_000254.
variant 1235 - 1235 S -> R (in CF) /FTId=VAR_000255.
variant 1244 - 1244 G -> E (in CF) /FTId=VAR_000256.
variant 1249 - 1249 G -> E (in CF) /FTId=VAR_000257.
variant 1251 - 1251 S -> N (in CF) /FTId=VAR_000258.
variant 1255 - 1255 S -> P (in CF) /FTId=VAR_000259.
variant 1270 - 1270 D -> N (in CF; dbSNP:rs11971167) /FTId=VAR_000260.
variant 1282 - 1282 W -> R (in CF) /FTId=VAR_000261.
variant 1283 - 1283 R -> M (in CF) /FTId=VAR_000262.
variant 1286 - 1286 F -> S (in CF) /FTId=VAR_000263.
variant 1291 - 1291 Q -> H (in CF) /FTId=VAR_000264.
variant 1291 - 1291 Q -> R (in CF) /FTId=VAR_000265.
variant 1303 - 1303 N -> H (in CF) /FTId=VAR_000266.
variant 1303 - 1303 N -> K (in CF) /FTId=VAR_000267.
variant 1349 - 1349 G -> D (in CF) /FTId=VAR_000268.
variant 1364 - 1364 A -> V (in CBAVD) /FTId=VAR_000269.
variant 1397 - 1397 V -> E (in CF) /FTId=VAR_000270.
variant 1453 - 1453 R -> W (in dbSNP:rs4148725) /FTId=VAR_048152.
keyword 1 - 1480 3D-structure
keyword 1 - 1480 Alternative splicing
keyword 1 - 1480 ATP-binding
keyword 1 - 1480 Chloride
keyword 1 - 1480 Chloride channel
keyword 1 - 1480 Complete proteome
keyword 1 - 1480 Disease mutation
keyword 1 - 1480 Endosome
keyword 1 - 1480 Glycoprotein
keyword 1 - 1480 Hydrolase
keyword 1 - 1480 Ion transport
keyword 1 - 1480 Ionic channel
keyword 1 - 1480 Membrane
keyword 1 - 1480 Nucleotide-binding
keyword 1 - 1480 Phosphoprotein
keyword 1 - 1480 Polymorphism
keyword 1 - 1480 Repeat
keyword 1 - 1480 Transmembrane
keyword 1 - 1480 Transmembrane helix
keyword 1 - 1480 Transport
keyword 1 - 1480 Ubl conjugation
Molecular Weight 1 - 1480 168142
2 hits 1 - 1480 PF00005
2 hits 1 - 1480 PF00664
1 hit 1 - 1480 PS00211
2 hits 1 - 1480 PS50893
2 hits 1 - 1480 PS50929

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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