CFLAR / FLIP

CASP8 and FADD-like apoptosis regulator

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and -10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPa, b, g, and d, respectively.

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Products

ELISA Kits (5)

Type

Development Kit (1)

Sandwich (4)

Target

CFLAR / FLIP (5)

Reactivity

Human (4)

Mouse (1)

Product Group

DevKit DuoPlus (1)

Format

96-Well Strip Plate (4)

Antibody Pair and Standard (1)

Publications

No (5)

Sample Type

Cell Lysates (2)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

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Human CFLAR / FLIP (Sandwich ELISA) ELISA Kit - LS-F17824

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse CFLAR / FLIP (Sandwich ELISA) ELISA Kit - LS-F17825

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human CFLAR / FLIP (Sandwich ELISA) ELISA Kit - LS-F25585

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$902

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DevKit DuoPlus Human CFLAR / FLIP ELISA Development Kit - LS-F72262

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,370; 1000 Wells/$2,059

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Human CFLAR / FLIP (Sandwich ELISA) ELISA Kit - LS-F34953

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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