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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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CFL2 / Cofilin 2
cofilin 2 (muscle)
CFL2 / Cofilin 2 is an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
| Gene Name: | cofilin 2 (muscle) |
| Family/Subfamily: | Cytoskeleton |
| Synonyms: | CFL2, Cofilin 2, Cofilin-2, NEM7, Cofilin 2 (muscle), Cofilin, muscle isoform |
| Target Sequences: | NM_138638 NP_619579.1 Q9Y281 |
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