CFI / Complement Factor I

complement factor I

CFI / Complement Factor I is a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

CFI / Complement Factor I (7)

Publications

No (7)

Tag

GST, N-terminus (1)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Mouse CFI / Complement Factor I Protein (Recombinant His) (aa358-603) - LS-G24581

Source:

E. coli

Tag:

His

Molecular Weight:

31.3 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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Human CFI / Complement Factor I Protein (Recombinant His-GST) (aa28-243) - LS-G14562

Source:

E. coli

Tag:

His-GST

Molecular Weight:

56.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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CFI / Complement Factor I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123334

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.72 kDa

Price:

100 µg/$710

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Human CFI / Complement Factor I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75295

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.72 kDa

Price:

20 µg/$215

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Human CFI / Complement Factor I Protein (Recombinant GST, N-terminus) (aa19-118) - LS-G58937

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CFI / Complement Factor I Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65298

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63.4 kDa

Price:

20 µg/$1,107

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Human CFI / Complement Factor I Protein (Recombinant His) (aa340-583) - LS-G14563

Source:

E. coli

Tag:

His

Molecular Weight:

29.1 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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