CFHR1 is a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
|Gene Name:||complement factor H-related 1|
|Synonyms:||CFHR1, CFHL1P, CFHL, CFHL1, Complement factor H-related 1, FHR-1, H36-2, HFL2, H factor (complement)-like 2, H36, H36-1, HFL1, FHR1, H factor-like protein 1, CFHR1P, H factor (complement)-like 1, H-factor-like 1|
|Target Sequences:||NM_002113 NP_002104.2 Q03591|
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