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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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CFH / Complement Factor H
complement factor H
CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease. Guo Lu, Weihong Liu, Xinying Huang, Yanxin Zhao. Arquivos de neuro-psiquiatria. 2020 February;78:76-80. [Full Text Article]
[PubMed:32022122]
3
Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site. Xiaocui Chen, Liqun Li, Fuhong Liu, Josephine Hoh, Carolyn M Kapron, Ju Liu. Journal of immunology (Baltimore, Md. : 1950). 2019 Feb;202:1210-1218. [Full Text Article]
[PubMed:30642982]
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Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS. Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Rossella Piras, Caterina Mele, Matteo Breno, Alessandra Cremaschi, Elena Bresin, Roberta Donadelli, Silvia Alizzi, Antonio Amoroso, Ariela Benigni, Giuseppe Remuzzi , Marina Noris. Frontiers in immunology. 2019 May;10:853. [Full Text Article]
[PubMed:31118930]
[PMC:PMC6504697]
Related Antibodies: LS-C58560.
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins10<sup> Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany. Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius , Antje J Baeumner, Mark-Steven Steiner, Mihály Józsi , Erik J M Toonen, Diana Pauly , SciFiMed consortium. Frontiers in immunology. 2021 Mar;12:660194. [Full Text Article]
[PubMed:33868311]
[PMC:PMC8044877]
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CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis. Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J H Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris. Frontiers in genetics. 2021 Jun;12:670727. [Full Text Article]
[PubMed:34211499]
[PMC:PMC8240960]
Related Antibodies: LS-C58560.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).