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CFH / Complement Factor H

complement factor H

CFH / Complement Factor H is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene Name: complement factor H
Synonyms: CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement)
Target Sequences: NM_000186 NP_000177.2 P08603

Publications (6)

1
VEGF regulates local inhibitory complement proteins in the eye and kidney. The Journal of clinical investigation. 2017 January;127:199-214. [Full Text Article] [PubMed:27918307] [PMC:PMC5199702]
2
Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease. Guo Lu, Weihong Liu, Xinying Huang, Yanxin Zhao. Arquivos de neuro-psiquiatria. 2020 February;78:76-80. [Full Text Article] [PubMed:32022122]
3
Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site. Xiaocui Chen, Liqun Li, Fuhong Liu, Josephine Hoh, Carolyn M Kapron, Ju Liu. Journal of immunology (Baltimore, Md. : 1950). 2019 Feb;202:1210-1218. [Full Text Article] [PubMed:30642982]
4
Rare Functional Variants in Complement Genes and Anti-FH Autoantibodies-Associated aHUS. Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Rossella Piras, Caterina Mele, Matteo Breno, Alessandra Cremaschi, Elena Bresin, Roberta Donadelli, Silvia Alizzi, Antonio Amoroso, Ariela Benigni, Giuseppe Remuzzi , Marina Noris. Frontiers in immunology. 2019 May;10:853. [Full Text Article] [PubMed:31118930] [PMC:PMC6504697] Related Antibodies: LS-C58560.
5
A Family Affair: Addressing the Challenges of Factor H and the Related Proteins10<sup> Department of Ophthalmology, University Hospital Regensburg, Regensburg, Germany. Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius , Antje J Baeumner, Mark-Steven Steiner, Mihály Józsi , Erik J M Toonen, Diana Pauly , SciFiMed consortium. Frontiers in immunology. 2021 Mar;12:660194. [Full Text Article] [PubMed:33868311] [PMC:PMC8044877]
6
CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis. Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J H Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris. Frontiers in genetics. 2021 Jun;12:670727. [Full Text Article] [PubMed:34211499] [PMC:PMC8240960] Related Antibodies: LS-C58560.
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ELISA Kits (26)
Competitive EIA (1)
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CFH / Complement Factor H (26)
Human (9)
Mouse (7)
Rat (4)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
96-Well Microplate (2)
96-Well Strip Plate (24)
No (23)
Yes (3)
Cell Culture Supernatants (7)
Cell Lysates (2)
Cell Supernatant (1)
Plasma (21)
Serum (21)
Tissue Homogenates (5)
Urine (2)
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$913
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Microplate
Human
23.44 - 1500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$610
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$795
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
4.7 - 300 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
23.438 - 1500 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CFH / Complement Factor H ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
CFH / Complement Factor H ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$795
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
50 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CFH / Complement Factor H ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
23.438 - 1500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
23.44 - 1500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$731
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1560 - 100000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$669
CFH / Complement Factor H ELISA Kit
Select
Sandwich
96-Well Microplate
Human
2 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$672
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).