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Unfortunately, the antibody (ID:40859) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CETN2 / Centrin 2

centrin, EF-hand protein, 2

Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).

Gene Name: centrin, EF-hand protein, 2
Synonyms: CETN2, Caltractin isoform 1, Centrin-2, CALT, Caltractin, isoform 1, Centrin, EF-hand protein, 2, CEN2, Centrin 2
Target Sequences: NM_004344 NP_004335.1 P41208
Featured Image

Featured CETN2 / Centrin 2 Antibody

LS-B13798 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (1)

1
Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins. Dantas TJ, Wang Y, Lalor P, Dockery P, Morrison CG. The Journal of cell biology. 2011 193:307-18. [PubMed:21482720] [PMC:PMC3080269]

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
CETN2 / Centrin 2 Rabbit IgG Polyclonal Unconjugated Human IHC-P, ELISA aa1-172 No Primary
Anti-CETN2 / Centrin 2 Antibody (aa1-172) IHC-plus™ LS-B13798
Immunohistochemistry - Paraffin Image
Rabbit Polyclonal (IgG) to Human CETN2 / Centrin 2
Human
IHC - Paraffin, ELISA
Unconjugated
CETN2 / Centrin 2 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, IF, WB No Primary
Anti-CETN2 / Centrin 2 Antibody LS-C334034
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal (IgG) to Human CETN2 / Centrin 2
Human, Mouse, Rat
IHC, Immunofluorescence, Western blot
Unconjugated
CETN2 / Centrin 2 Rabbit IgG Polyclonal Biotin Conjugated Human IHC-P, WB, ELISA No Primary
Anti-CETN2 / Centrin 2 Antibody (Biotin) LS-C318971
Immunohistochemistry - Paraffin Image
Rabbit Polyclonal (IgG) to Human CETN2 / Centrin 2
Human
IHC - Paraffin, Western blot, ELISA
Biotin Conjugated
CETN2 / Centrin 2 Rabbit IgG Polyclonal HRP Conjugated Human IHC-P, WB, ELISA No Primary
Anti-CETN2 / Centrin 2 Antibody (HRP) LS-C317905
Immunohistochemistry - Paraffin Image
Rabbit Polyclonal (IgG) to Human CETN2 / Centrin 2
Human
IHC - Paraffin, Western blot, ELISA
HRP Conjugated
CETN2 / Centrin 2 Rabbit IgG Polyclonal FITC Conjugated Human IHC-P, WB, ELISA No Primary
Anti-CETN2 / Centrin 2 Antibody (FITC) LS-C317897
Immunohistochemistry - Paraffin Image
Rabbit Polyclonal (IgG) to Human CETN2 / Centrin 2
Human
IHC - Paraffin, Western blot, ELISA
FITC Conjugated
CETN2 / Centrin 2 Rabbit IgG Polyclonal Unconjugated Human IHC-P, ELISA aa1-172 No Primary
Anti-CETN2 / Centrin 2 Antibody (aa1-172) LS-C375443
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human CETN2 / Centrin 2
Human
IHC - Paraffin, ELISA
Unconjugated
CETN2 / Centrin 2 Mouse IgG1,k Monoclonal 3F8 Unconjugated Human WB, ELISA No Primary
Anti-CETN2 / Centrin 2 Antibody (clone 3F8) LS-C196900
Enzyme-Linked Immunosorbent Assay Image
Mouse Monoclonal [clone 3F8] (IgG1,k) to Human CETN2 / Centrin 2
Human
Western blot, ELISA
Unconjugated
CETN2 / Centrin 2 Rabbit Polyclonal Unconjugated Human, Mouse, Rat ICC, IF, WB No Primary
Anti-CETN2 / Centrin 2 Antibody LS-C482434
Immunofluorescence Image
Western blot Image
Rabbit Polyclonal to Human CETN2 / Centrin 2
Human, Mouse, Rat
ICC, Immunofluorescence, Western blot
Unconjugated
CETN2 / Centrin 2 Rabbit Polyclonal Unconjugated Human, Mouse, Rat IF, WB No Primary
Anti-CETN2 / Centrin 2 Antibody LS-C341785
Rabbit Polyclonal to Human CETN2 / Centrin 2
Human, Mouse, Rat
Immunofluorescence, Western blot
Unconjugated
CETN2 / Centrin 2 Mouse IgG Polyclonal Unconjugated Human WB No Primary
Anti-CETN2 / Centrin 2 Antibody LS-C306912
Mouse Polyclonal (IgG) to Human CETN2 / Centrin 2
Human
Western blot
Unconjugated
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant CETN2 / Centrin 2 His Human E. coli
Human CETN2 / Centrin 2 Recombinant (His) Protein - LS-G1076
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
E. coli Expression System
His
Unpurified / Lyophilized
Recombinant CETN2 / Centrin 2 His Human E. coli
Human CETN2 / Centrin 2 Recombinant (His) Protein - LS-G18604
E. coli Expression System
His
Unpurified / Lyophilized
21.9 kDa
Recombinant CETN2 / Centrin 2 His + SUMO Human E. coli Is full length
Human CETN2 / Centrin 2 Recombinant (His + SUMO) Protein (Full Length) - LS-G20599
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
E. coli Expression System
His + SUMO
Unpurified / Lyophilized
aa 1-172
35.7 kD
Recombinant CETN2 / Centrin 2 GST Human Wheat
Human CETN2 / Centrin 2 Recombinant (GST) Protein - LS-G27896
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Wheat Wheat Germ Extract
GST
Unpurified / Lyophilized
44.66 kDa
CETN2 / Centrin 2 None E. coli
E. coli CETN2 / Centrin 2 Protein (Met1-Tyr171) - LS-G50636
None
Unpurified
Met1-Tyr171
CETN2 / Centrin 2 None Human
Human CETN2 / Centrin 2 Protein (Met1-Tyr172) - LS-G50637
None
Unpurified
Met1-Tyr172
CETN2 / Centrin 2 None Human
Human CETN2 / Centrin 2 Protein (Met1-Tyr172) - LS-G52705
None
Unpurified
Met 1-Tyr 172
21.2 kDa

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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