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CENPU / MLF1IP

Centromere protein U

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Gene Name: Centromere protein U
Synonyms: CENPU, CENP-U, CENP50, CENPU50, Centromere protein U, ICEN24, KLIP1, Polo-box-interacting protein 1, MLF1-interacting protein, CENP-50, Centromere protein of 50 kDa, MLF1 interacting protein, MLF1IP, PBIP1
Target Sequences: NM_024629 NP_078905.2 Q71F23

Publications (2)

1
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS. Molecular cell. 2006 24:409-22. [PubMed:17081991]
2
Centromere protein U expression promotes non-small-cell lung cancer cell proliferation through FOXM1 and predicts poor survival. Wang X, Chen D, Gao J, Long H, Zha H, Zhang A, Shu C, Zhou L, Yang F, Zhu B, Wu W. Cancer management and research. 2018 December;10:6971-6984. [Full Text Article] [PubMed:30588102] [PMC:PMC6298391] Related Antibodies: LS-C158151.

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CENPU / MLF1IP (2)
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CENPU / MLF1IP Protein
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E. coli
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100 µg/$361; 500 µg/$739; 20 µg/$261
CENPU / MLF1IP Protein - 12.5% SDS-PAGE of human MLF1IP stained with Coomassie Blue
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45.1 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).