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CENPJ / LAP

centromere protein J

CENPJ / LAP is a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.

Gene Name: centromere protein J
Synonyms: CENPJ, BM032, Centromere protein J, CENP-J, LAP, LYST-interacting protein 1, LIP1, LYST-interacting protein LIP7, SASS4, Sas-4, LYST-interacting protein LIP1, CPAP, LAG-3-associated protein, MCPH6, SCKL4
Target Sequences: NM_018451 NP_060921.3 Q9HC77

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
CENPJ / LAP (6)
No (6)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
CENPJ / LAP Protein - Recombinant Centromere Protein J By SDS-PAGE
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E. coli
6His, N-terminus
26.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
CENPJ / LAP Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CENPJ / LAP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
152.8 kDa
20 µg/$215
CENPJ / LAP Protein - Recombinant Centromere Protein J By SDS-PAGE
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E. coli
His-T7
27.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
CENPJ / LAP Protein - 12.5% SDS-PAGE of human CENPJ stained with Coomassie Blue
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Wheat Germ Extract
GST
69.6 kDa
10 µg/$479; 25 µg/$670
CENPJ / LAP Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
152.8 kDa
100 µg/$710
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).