CENPE

centromere protein E, 312kDa

Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.

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Proteins (3)

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Recombinant (3)

Target

CENPE (3)

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No (3)

Tag

GST, N-terminus (1)

His-T7 (2)

Species

Human (2)

Rat (1)

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E. coli (2)

Wheat Germ Extract (1)

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Human CENPE Protein (Recombinant His-T7) (aa2450-2590) - LS-G11908

Source:

E. coli

Tag:

His-T7

Molecular Weight:

20.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human CENPE Protein (Recombinant GST, N-terminus) (aa309-419) - LS-G58099

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat CENPE Protein (Recombinant His-T7) (aa2222-2361) - LS-G11910

Source:

E. coli

Tag:

His-T7

Molecular Weight:

20.4 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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