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CENPC / CENP-C
centromere protein C
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
| Gene Name: | centromere protein C |
| Synonyms: | CENPC, CENP-C 1, CENPC1, Centromere autoantigen C, Centromere protein C 1, CENP-C, Centromere autoantigen C1, Centromere protein c, Hcp-4, MIF2, ICEN7 |
| Target Sequences: | NM_001812 NP_001803.2 Q03188 |
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