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CELSR3 belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation.
Gene Name: | cadherin, EGF LAG seven-pass G-type receptor 3 |
Family/Subfamily: | GPCR , Orphan-U |
Synonyms: | CELSR3, Anchor protein, Cadherin family member 11, CDHF11, EGF-like protein 1, EGF-like-domain, multiple 1, Epidermal growth factor-like 1, Flamingo homolog 1, FMI1, KIAA0812, MEGF2, Megf3, HFMI1, Multiple EGF-like domains 2, RESDA1, EGFL1 |
Target Sequences: | NM_001407 NP_001398.2 Q9NYQ7 |
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