CEB1 / HERC5

HECT and RLD domain containing E3 ubiquitin protein ligase 5

Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CEB1 / HERC5 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CEB1 / HERC5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87549

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.7 kDa

Price:

20 µg/$215

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Human CEB1 / HERC5 Protein (Recombinant GST, N-terminus) (aa915-1024) - LS-G62423

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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CEB1 / HERC5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112729

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.7 kDa

Price:

100 µg/$710

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Human CEB1 / HERC5 Protein (Recombinant His) - LS-G2885

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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