CDKN3 / KAP

cyclin-dependent kinase inhibitor 3

CDKN3 encodes a dual specificity protein phosphatase which has been identified as a cyclin-dependent kinase inhibitor and has been shown to interact with, and dephosphorylate human CDK2 kinase. CDKN3 has also been shown to associate with human CDK3 and CDC2. The protein has been reported to remove phosphate from tyrosine residues in model substrates in vitro; however, a mutant protein that bears a lesion in the putative active site cysteine has been shown to lose catalytic activity. In HeLa cells, CDKN3 has been demonstrated to be expressed at the G1 to S transition and overexpression of wild-type CDKN3 has been shown to delay progression through the cell cycle. This gene has been reported to be deleted, mutated, or overexpressed in several kinds of cancers, including breast and prostate cancers.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

CDKN3 / KAP (9)

Publications

No (9)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His-GST (1)

Myc-DDK (Flag) (4)

Species

Human (7)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

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CDKN3 / KAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125133

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.2 kDa

Price:

100 µg/$494

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CDKN3 / KAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116113

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.6 kDa

Price:

100 µg/$494

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Human CDKN3 / KAP Protein (Recombinant His-GST) (aa1-212) - LS-G24812

Source:

E. coli

Tag:

His-GST

Molecular Weight:

53.8 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CDKN3 / KAP Protein (Recombinant GST) (Full Length) - LS-G27881

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.44 kDa

Price:

2 µg/$439

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Human CDKN3 / KAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75361

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

23.6 kDa

Price:

20 µg/$150

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Human CDKN3 / KAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75364

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.2 kDa

Price:

20 µg/$150

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Human CDKN3 / KAP Protein (Recombinant GST, N-terminus) (aa51-140) - LS-G58090

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CDKN3 / KAP Protein (Recombinant 6His, N-terminus) (aa1-212) - LS-G57141

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human CDKN3 / KAP Protein (Recombinant His) - LS-G1048

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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