Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

CDKN2A

cyclin-dependent kinase inhibitor 2A

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform 6 may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.

Gene Name: cyclin-dependent kinase inhibitor 2A
Synonyms: CDKN2A, ARF, Cdk4 inhibitor, CDK4 inhibitor p16-INK4, INK4, INK4A, Multiple tumor suppressor 1, MTS-1, MTS1, p16-INK4, p16-INK4A, p16INK4, p19, p14, p16, p16 INK4A, p16INK4A, p14ARF, TP16, CDK4I, CDKN2, CMM2, MLM, p19ARF
Target Sequences: NM_000077 NP_000068.1 P42771


☰ Filters
CDKN2A ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $590.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $590.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $700.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $870.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1plate   $700.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $790.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1plate   $720.00
CDKN2A ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
CDKN2A ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $790.00
CDKN2A ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $600.00
CDKN2A ELISA Kit
Select
Custom
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
CDKN2A ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
CDKN2A ELISA Kit
Select
Custom
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
CDKN2A ELISA Kit
Select
Custom
96-Well Strip Plate
Porcine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
CDKN2A ELISA Kit
Select
Custom
96-Well Strip Plate
Rabbit
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1plate   $850.00
CDKN2A ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1plate   $700.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1plate   $510.00
CDKN2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1plate   $510.00
Viewing 1-20 of 20 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).