Menu
Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

CDKN1B / p27 Kip1

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms: CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4
Target Sequences: NM_004064 NP_004055.1 P46527

Publications (2)

1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB) [PubMed:19451650] [PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8. [PubMed:22139837] [PMC:PMC3265888]

Viewing 1-17 of 17 items
CDKN1B / p27 Kip1 Protein - Purified recombinant protein CDKN1B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc + DDK
21.9 kDa
20µg   $890.00
Select
293T Cells
Myc + DDK
21.9 kDa
20µg   $195.00
CDKN1B / p27 Kip1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
21.9 kDa
100µg   $365.00
Select
E. coli
GST,N-terminus
39 kDa
200µg   $315.00
Select
E. coli
GST,N-terminus
35 kDa
200µg   $315.00
CDKN1B / p27 Kip1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
CDKN1B / p27 Kip1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
CDKN1B / p27 Kip1 Protein
Select
E. coli
6His,N-terminus
22 kDa
10µg   $215.00; 50µg   $275.00; 100µg   $325.00; 500µg   $875.00
CDKN1B / p27 Kip1 Protein
Select
Sf9 Cells
DDK,C-terminus
22.1 kDa
20µg   $485.00
CDKN1B / p27 Kip1 Protein
Select
E. coli
His,C-terminus
Less than 0.1 EU/µg protein (determined by LAL method).
24.2 kDa
10µg   $395.00
CDKN1B / p27 Kip1 Protein - Recombinant Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) by SDS-PAGE
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
25.8kDa
10µg   $215.00; 50µg   $305.00; 200µg   $445.00; 100µg   $395.00; 1mg   $1,290.00; 500µg   $575.00
CDKN1B / p27 Kip1 Protein - Recombinant Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) by SDS-PAGE
Select
E. coli
HIS + T7, N-Terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.8kDa
10µg   $205.00; 50µg   $285.00; 200µg   $405.00; 100µg   $355.00; 1mg   $1,080.00; 500µg   $485.00
CDKN1B / p27 Kip1 Protein - 12.5% SDS-PAGE of human CDKN1B stained with Coomassie Blue
Select
Wheat Germ Extract
GST
47.52 kDa
10µg   $425.00; 25µg   $590.00
Select
E. coli
6His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.2 kDa
10µg   $295.00; 50µg   $545.00
CDKN1B / p27 Kip1 Protein
Select
E. coli
His
100µg   0.25mg/ml   $315.00; 0.5mg   0.25mg/ml   $695.00
Select
E. coli
6His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.2kD
10µg   $265.00; 50µg   $465.00; 500µg   $1,605.00; 1mg   $2,310.00
Select
E. coli
6His,N-terminus
5µg   $195.00; 20µg   $255.00; 1mg   $2,850.00

Viewing 1-17 of 17 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).