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CDKN1B / p27 Kip1

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms: CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4
Target Sequences: NM_004064 NP_004055.1 P46527

Publications (6)

1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB) [PubMed:19451650] [PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8. [PubMed:22139837] [PMC:PMC3265888]
3
Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. Landon J Inge, Aaron J Fowler, Kimberly M Paquette, Amanda L Richer, Nhan Tran, Ross M Bremner. The Journal of thoracic and cardiovascular surgery. 2013 February;145:531-8. [Full Text Article] [PubMed:23142123] Related Antibodies: LS-C335975.
4
Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cells. Jun-Yan Cai, Tong-Tong Xu, Ye Wang, Jing-Jian Chang, Jian Li, Xiao-Yang Chen, Xi Chen, Yi-Fei Yin, Xue-Jun Ni. International journal of oncology. 2018 Dec;53:2758-2768. [Full Text Article] [PubMed:30272277] Related Antibodies: LS-C17115.
5
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-?B) pathway. Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang. Bioengineered. 2022 April;13:10098-10110. [Full Text Article] [PubMed:35435119] [PMC:PMC9162013] Related Antibodies: LS-C389941.
6
A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-ß2 signaling. Chandrani Mondal, Majo J Gacha-Garay, Kathryn A Larkin, Rebecca C Adikes, Julie S Di Martino, Chen-Chi Chien, Madison Fraser, Ireti Eni-Aganga, Esperanza Agullo-Pascual, Katarzyna Cialowicz, Umut Ozbek, Alexandra Naba, Angelo Gaitas, Tian-Ming Fu, Srigokul Upadhyayula, Eric Betzig, David Q Matus, Benjamin L Martin, Jose Javier Bravo-Cordero. Cell reports. 2022 September;40:111358. [Full Text Article] [PubMed:36130489] [PMC:PMC9596226] Related Antibodies: LS-B3943.
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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
CDKN1B / p27 Kip1 (13)
No (13)
6His, N-terminus (3)
DDK,C-terminus (1)
GST (1)
GST, N-terminus (2)
His (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (3)
Human (11)
Mouse (1)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Sf9 Cells (1)
Wheat Germ Extract (3)
Purified (5)
Low endotoxin level (2)
CDKN1B / p27 Kip1 Protein - Purified recombinant protein CDKN1B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65327
HEK 293 Cells
Myc-DDK (Flag)
21.9 kDa
20 µg/$1,107
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant 6His, N-terminus) (Met1-Thr198) - LS-G38818
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
CDKN1B / p27 Kip1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant GST, N-terminus) (aa99-198) - LS-G58085
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CDKN1B / p27 Kip1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant GST, N-terminus) (aa100-198) - LS-G58087
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CDKN1B / p27 Kip1 Protein - 12.5% SDS-PAGE of human CDKN1B stained with Coomassie Blue
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant GST) (Full Length) - LS-G27875
Wheat Germ Extract
GST
47.52 kDa
10 µg/$479; 25 µg/$670
CDKN1B / p27 Kip1 Protein
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant 6His, N-terminus) (Ser2-Thr198) - LS-G26453
E. coli
6His, N-terminus
22 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
CDKN1B / p27 Kip1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
CDKN1B / p27 Kip1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100202
HEK 293 Cells
Myc-DDK (Flag)
21.9 kDa
100 µg/$494
CDKN1B / p27 Kip1 Protein - Recombinant Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) by SDS-PAGE
Select
Mouse CDKN1B / p27 Kip1 Protein (Recombinant) (Ser2-Thr197) - LS-G133686
E. coli
None
25.8kDa
10 µg/$249; 50 µg/$307; 200 µg/$482; 100 µg/$385; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480
CDKN1B / p27 Kip1 Protein - Recombinant Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) by SDS-PAGE
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant His-T7, N-terminus) (Met1-Thr198) - LS-G133307
E. coli
His-T7, N-terminus
25.8kDa
10 µg/$243; 50 µg/$291; 200 µg/$402; 100 µg/$339; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant 6His, N-terminus) (Met1-Thr198) - LS-G140121
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.2 kDa
10 µg/$317; 50 µg/$524
CDKN1B / p27 Kip1 Protein
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant DDK,C-terminus) - LS-G142400
Sf9 Cells
DDK,C-terminus
22.1 kDa
20 µg/$677
CDKN1B / p27 Kip1 Protein
Select
Human CDKN1B / p27 Kip1 Protein (Recombinant His) - LS-G1521
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
Human CDKN1B / p27 Kip1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75360
293T Cells
Myc-DDK (Flag)
21.9 kDa
20 µg/$150
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