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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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CDKN1B / p27 Kip1

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Gene Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Synonyms: CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4
Target Sequences: NM_004064 NP_004055.1 P46527

Publications (2)

1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB) [PubMed:19451650] [PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8. [PubMed:22139837] [PMC:PMC3265888]

Viewing 1-9 of 9 items
CDKN1B / p27 Kip1 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1plate   $700.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $490.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
3.125 - 200 pg/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate   $590.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $790.00
CDKN1B / p27 Kip1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate   $550.00

Viewing 1-9 of 9 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).