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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Unfortunately, the antibody (ID:300682) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CDK7

cyclin-dependent kinase 7

Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

Gene Name: cyclin-dependent kinase 7
Family/Subfamily: Protein Kinase , CDC2/CDK
Synonyms: CDK7, 39 kDa protein kinase, CDK-activating kinase, CDK-activating kinase 1, CDKN7, Cell division protein kinase 7, Cyclin-dependent kinase 7, HCAK, Protein kinase, Mpk-7, Serine/threonine kinase stk1, CAK, CAK1, Crk4, Kinase subunit of CAK, MO15, p39 Mo15, p39MO15, STK1
Target Sequences: NM_001799 NP_001790.1 P50613

Filtered By: None
Target
cdk7 (106)
Reactivity
Human (96)
Mouse (36)
Rat (21)
Bat (8)
Bovine (13)
Chicken (4)
Chimpanzee (10)
Dog (8)
Guinea pig (8)
Hamster (4)
Horse (12)
Monkey (8)
Orangutan (3)
Pig (13)
Rabbit (4)
Zebrafish (4)
Application
IHC (51)
IHC-Fr (5)
IHC-P (16)
WB (98)
Flo (4)
DB (10)
ELISA (33)
ICC (6)
IF (7)
IP (20)
Peptide-ELISA (4)
PLA (1)
Host
rabbit (81)
mouse (24)
goat (1)
Isotype
IgG (64)
IgG1 (4)
IgG2a,k (2)
IgG2b (15)
IgG2b,k (1)
Clonality
monoclonal mc (24)
polyclonal pc (82)
Clone
1G5 (1)
2141C4a (2)
E3E (1)
IMD-26 (3)
MO1 (2)
MO-1 (1)
Mo-1.1 (1)
Format
AP Conjugated (5)
APC (1)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (13)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (12)
HRP Conjugated (10)
Magnetic beads Conjugated (1)
PE Conjugated (6)
Sepharose Conjugated (1)
Unconjugated (51)
Epitope
pThr170 (17)
C-Terminus (15)
aa12-295 (10)
Internal (7)
N-Terminus (4)
aa329-346 (2)
Asn166 (1)
Leu325 (1)
aa110-190 (1)
aa136-185 (1)
aa260-340 (1)
aa291-340 (1)
aa31-346 (1)
pSer164/ pThr170 (1)
Publications
No (106)
Showing 1-25 of 106 results

CDK7 Antibody (clone E3E) IHC-plus™ LS-B7848
Mouse Monoclonal [clone E3E] (IgG2a,k) to Human CDK7
Human
ELISA IHC IHC-P IP WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-CDK7 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7848 dilution 1:200.
Western blot Image
Anti-CDK7 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7848 dilution 1:200.
Western blot Image

CDK7 Antibody LS-C79007
Mouse Monoclonal (IgG1) to Human CDK7
Human
Flo ICC IP WB
Unconjugated
50µg 0.1mg/ml  $385.00

CDK7 Antibody (phospho-Ser164/ pThr170) IHC-plus™ LS-B1971
Rabbit Polyclonal (IgG) to Human CDK7
Human
IF IHC IHC-P
Unconjugated
50µl  $425.00
Anti-CDK7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1971 concentration 10 ug/ml.
Untreated Hela cells (Lower Panel), or overnight nocodazole treated Hela cells (Upper Panel) stained with purified rabbit polyclonal antibody against Ser167/Thr170 phosphorylated CAK, followed by Rhodamine Red-X conjugated goat anti-rabbit IgG and DAPI.
Anti-CDK7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1971 concentration 10 ug/ml.
Untreated Hela cells (Lower Panel), or overnight nocodazole treated Hela cells (Upper Panel) stained with purified rabbit polyclonal antibody against Ser167/Thr170 phosphorylated CAK, followed by Rhodamine Red-X conjugated goat anti-rabbit IgG and DAPI.

CDK7 Antibody (clone 2141C4a) LS-C342422
Mouse Monoclonal [clone 2141C4a] (IgG1) to Human CDK7
Human
DB Flo ICC IF IP WB
Unconjugated
100µg 0.1mg/ml  $375.00
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CDK7 mAb.
Detection of human CDK7 by Western blot. Samples: Whole cell lysate (50 ug) from HeLa cells. Predicted molecular weight: 39 kDa
Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CDK7 mAb.
Detection of human CDK7 by Western blot. Samples: Whole cell lysate (50 ug) from HeLa cells. Predicted molecular weight: 39 kDa

CDK7 Antibody (C-Terminus) LS-C6009
Mouse Monoclonal (IgG2b) to Human CDK7
Mouse, Human
Flo IF IHC IHC-Fr IP WB
Unconjugated
50µg 50µl  $545.00

CDK7 Antibody LS-C123217
Mouse Monoclonal (IgG2b) to Human CDK7
Human
ICC IF IHC IHC-Fr IHC-P WB
Unconjugated
100µg  $530.00

CDK7 Antibody LS-C331642
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded mouse brain using CDK7 antibodyat dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human colon using CDK7 antibodyat dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using CDK7 antibodyat dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human colon using CDK7 antibodyat dilution of 1:200 (40x lens).

CDK7 Antibody LS-C6014
Mouse Monoclonal (IgG2b) to Human CDK7
Rat, Human
ICC IHC IHC-P IP WB
Unconjugated
100µl  $530.00

CDK7 Antibody (clone IMD-26) LS-C171099
Mouse Monoclonal [clone IMD-26] (IgG2b) to Human CDK7
Human
ICC IHC IHC-Fr WB
Unconjugated
100µg 1ml 1mg/ml  $295.00

CDK7 Antibody (clone 2141C4a) LS-C184363
Mouse Monoclonal [clone 2141C4a] (IgG1) to Human CDK7
Human
DB Flo ICC IP WB
Unconjugated
50µg 0.1mg/ml  $325.00
Immunofluorescent staining using CDK7 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CDK7 antibody.
Western blot of immunized recombinant protein using CDK7 antibody.
Immunofluorescent staining using CDK7 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CDK7 antibody.
Western blot of immunized recombinant protein using CDK7 antibody.

CDK7 Antibody (clone MO-1) LS-C179593
Mouse Monoclonal [clone MO-1] (IgG2b) to Human CDK7
Rat, Human
IHC IHC-P IP WB
Unconjugated
100µg 1mg/ml  $320.00
Immunohistochemistry Image
Western blot Image
Immunohistochemistry Image
Western blot Image

CDK7 Antibody (phospho-Thr170) LS-C97439
Rabbit Polyclonal to Human CDK7
Human
DB IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The CDK7-T170 antibody is used in Western blot to detect CDK7-T170 in Ramos tissue lysate.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The CDK7-T170 antibody is used in Western blot to detect CDK7-T170 in Ramos tissue lysate.

CDK7 Antibody (C-Terminus) LS-C6005
Mouse Monoclonal (IgG2b) to Human CDK7
Human
IHC IHC-Fr IP WB
Unconjugated
100µg  $815.00

CDK7 Antibody (C-Terminus, clone MO1) LS-C44181
Mouse Monoclonal [clone MO1] (IgG2b) to Human CDK7
Human
IHC IHC-Fr IP WB
Unconjugated
100µg 1mg/ml  $560.00

CDK7 Antibody LS-C677474
Rabbit Polyclonal (IgG) to Human CDK7
Human
ELISA IF IHC
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human breast cancer at dilution of 1:100
Immunofluorescent analysis of HeLa cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunohistochemistry of paraffin-embedded human breast cancer at dilution of 1:100
Immunofluorescent analysis of HeLa cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

CDK7 Antibody (aa136-185) LS-C117854
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CDK7 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from Raw264.7 cells, treated with Calyculin A 50ng/ml 30', using CDK7 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CDK7 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from Raw264.7 cells, treated with Calyculin A 50ng/ml 30', using CDK7 Antibody. The lane on the right is blocked with the synthesized peptide.

CDK7 Antibody (aa291-340) LS-C118601
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CDK7 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from 293 cells, using CDK7 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CDK7 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from 293 cells, using CDK7 Antibody. The lane on the right is blocked with the synthesized peptide.

CDK7 Antibody (phospho-Thr170) LS-C198787
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using CDK7 (Phospho-Thr170) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HeLa cells treated with Calyculin A 50nM 30', using CDK7 (Phospho-Thr170) Antibody. The lane on the right is blocked with the phospho peptide.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using CDK7 (Phospho-Thr170) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from HeLa cells treated with Calyculin A 50nM 30', using CDK7 (Phospho-Thr170) Antibody. The lane on the right is blocked with the phospho peptide.

CDK7 Antibody (C-Terminus) LS-C30821
Rabbit Polyclonal (IgG) to Human CDK7
Rat, Pig, Horse, Bat, Mouse, Bovine, Human
IHC IHC-P WB
Unconjugated
100µg  $325.00
CDK7 antibody LS-C30821 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CDK7 antibody LS-C30821 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CDK7 antibody LS-C30821 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CDK7 antibody LS-C30821 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CDK7 Antibody (phospho-Thr170) LS-C327048
Rabbit Polyclonal (IgG) to Human CDK7
Human
ELISA IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

CDK7 Antibody (phospho-Thr170) LS-C381325
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

CDK7 Antibody (aa110-190) LS-C382640
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00

CDK7 Antibody (aa260-340) LS-C382635
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Cdk7 antibody
Western blot of Cdk7 antibody

CDK7 Antibody LS-C403908
Rabbit Polyclonal (IgG) to Human CDK7
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human lung cancer using CDK7 Polyclonal Antibody at dilution of 1:30.
Western blot analysis of A549 cell , using CDK7 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry of Human lung cancer using CDK7 Polyclonal Antibody at dilution of 1:30.
Western blot analysis of A549 cell , using CDK7 Polyclonal Antibody at dilution of 1:500.

CDK7 Antibody LS-C409041
Mouse Monoclonal (IgG) to Human CDK7
Rat, Human
IHC IP WB
Unconjugated
50µl  $315.00; 100µl  $425.00; 200µl  $650.00
Western blot analysis of extracts of C6 cells.
Western blot analysis of extracts of C6 cells.
Showing 1-25 of 106 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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