CDK6

cyclin-dependent kinase 6

Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

CDK6 (10)

Publications

No (10)

Tag

GST (2)

GST, N-terminus (2)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (4)

Purification

Purified (2)

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CDK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126636

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.8 kDa

Price:

100 µg/$494

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Human CDK6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65225

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.8 kDa

Price:

20 µg/$1,107

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Human CDK6 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65226

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.8 kDa

Price:

20 µg/$1,107

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Human CDK6 Protein (Recombinant GST) (Full Length) - LS-G27870

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CDK6 Protein (Recombinant GST) (Full Length) - LS-G27872

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.49 kDa

Price:

2 µg/$439

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Human CDK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75123

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.8 kDa

Price:

20 µg/$150

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Human CDK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75124

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.8 kDa

Price:

20 µg/$150

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Human CDK6 Protein (Recombinant GST, N-terminus) (aa3-99) - LS-G58080

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CDK6 Protein (Recombinant GST, N-terminus) (aa226-326) - LS-G58079

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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CDK6 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99390

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.8 kDa

Price:

100 µg/$494

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