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CDK5RAP2

CDK5 regulatory subunit associated protein 2

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends.

Gene Name:	CDK5 regulatory subunit associated protein 2
Synonyms:	CDK5RAP2, Cep215, Centrosomal protein 215 kDa, MCPH3, C48, KIAA1633
Target Sequences:	NM_018249 NP_060719.4 Q96SN8

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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