CDK5R1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CDK5R1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CDK5R1 Protein (Recombinant GST) (Full Length) - LS-G31365

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.5 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CDK5R1 Protein (Recombinant GST, N-terminus) (aa208-307) - LS-G60899

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CDK5R1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75355

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.9 kDa

Price:

20 µg/$150

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CDK5R1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100166

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.9 kDa

Price:

100 µg/$494

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