CDK5R1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

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ELISA Kits (7)

Type

Cell-Based (1)

Custom (3)

Sandwich (3)

Target

CDK5R1 (7)

Reactivity

Human (3)

Mouse (2)

Rat (3)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

Publications

No (7)

Sample Type

Adherent Cell Cultures (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

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Human CDK5R1 (Sandwich ELISA) ELISA Kit - LS-F17798

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Bovine CDK5R1 (Custom ELISA) ELISA Kit - LS-F17799

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat CDK5R1 (Custom ELISA) ELISA Kit - LS-F17800

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse CDK5R1 (Custom ELISA) ELISA Kit - LS-F17801

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse/Human/Rat CDK5R1 (Cell-Based ELISA) ELISA Kit - LS-F3199

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Rat CDK5R1 (Sandwich ELISA) ELISA Kit - LS-F32868

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human CDK5R1 (Sandwich ELISA) ELISA Kit - LS-F32867

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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