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CDK20 / CCRK
cyclin-dependent kinase 20
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
| Gene Name: | cyclin-dependent kinase 20 |
| Family/Subfamily: | Protein Kinase , CDC2/CDK |
| Synonyms: | CDK20, CAK-kinase p42, Cell cycle related kinase, Cell cycle-related kinase, Cyclin-dependent kinase 20, p42, PNQALRE, CCRK, CDCH, CDK-activating kinase p42 |
| Target Sequences: | NM_012119 NP_036251.2 Q8IZL9 |
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