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CDK11B / CDC2L1

cyclin-dependent kinase 11B

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.

Gene Name: cyclin-dependent kinase 11B
Family/Subfamily: Protein Kinase , PITSLRE
Synonyms: CDK11B, CDK11, CDC-related protein kinase p58, CLK-1, Cyclin-dependent kinase 11B, CDC2L1, CDK11-p110, CDK11-p58, Cell division cycle 2-like 1, p58, p58 CLK-1, p58CLK-1, PITSLRE protein kinase alpha, PITSLRE B, PK58, PITSLREA, CDK11-p46, p58CDC2L1, Protein kinase p58, Protein kinase p58/gta
Target Sequences: NM_033486 NP_277021.2 P21127

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Products
Antibodies (12)
Primary (12)
CDK11B / CDC2L1 (12)
Human (12)
Mouse (10)
Rat (3)
Bovine (1)
Chicken (1)
Pig (1)
IHC (4)
IHC-P (2)
WB (9)
ELISA (3)
IF (2)
Peptide-ELISA (2)
rabbit (12)
IgG (10)
polyclonal pc (12)
Unconjugated (12)
10-90 aa, N-terminal (1)
N-Terminus (1)
aa10-59 (1)
No (12)
CDK11B / CDC2L1 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using CDK11A/CDK11B Polyclonal Antibody at dilution of 1:40.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CDK11B / CDC2L1 Antibody - Western blot of PITSLRE antibody
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDK11B / CDC2L1 Antibody - Staining HuvEc cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CDK11B / CDC2L1 Antibody - Immunohistochemical analysis of CDK11B staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Rat, Pig, Mouse, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
CDK11B / CDC2L1 Antibody - Western blot analysis of extracts from HepG2 cells and HUVEC cells, using CD2L1 antibody.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
CDK11B / CDC2L1 Antibody - Western blot analysis of lysates from HUVEC and HepG2 cells, using CDC2L1 Antibody. The lane on the right is blocked with the synthesized peptide.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CDK11B / CDC2L1 Antibody - Immunofluorescence analysis of HeLa cells using CDK11B Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CDK11B / CDC2L1 Antibody - All lanes: Anti-CDK11B Antibody at 1:1000 dilution. Lane 1: HeLa whole cell lysate. Lane 2: 293T/17 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 93 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$386
CDK11B / CDC2L1 Antibody - Western blot analysis of extracts of various cell lines, using CDK11B Antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CDK11B / CDC2L1 Antibody - Immunochemical staining of human CDK11B in human hepatoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
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CDK11B / CDC2L1 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).