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Unfortunately, the antibody (ID:79541) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



CDK1 / CDC2

cyclin-dependent kinase 1

Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration.

Gene Name: cyclin-dependent kinase 1
Family/Subfamily: Protein Kinase , CDC2/CDK
Synonyms: CDK1, CDC28A, CDC2, CDKN1, Cyclin-dependent kinase 1, p34 protein kinase, p34CDC2, CDC2a, Cell cycle controller CDC2, Cell division protein kinase 1, PSTAIR
Target Sequences: NM_001786 NP_001777.1 P06493

Publications (3)

1
Distinct forms of human CDC2 identified by novel monoclonal antibodies. Luks J, Draetta G, Bartek J. European journal of biochemistry / FEBS. 1992 207:169-76. [PubMed:1628647] Related Antibodies: LS-C18772.
2
Proteolysis and tyrosine phosphorylation of p34cdc2/cyclin B. The role of MCM2 and initiation of DNA replication to allow tyrosine phosphorylation of p34cdc2. Ye XS, Fincher RR, Tang A, McNeal KK, Gygax SE, Wexler AN, Ryan KB, James SW, Osmani SA. The Journal of biological chemistry. 1997 272:33384-93. [PubMed:9407133] Related Antibodies: LS-C18772.
3
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. Palmer A, Gavin AC, Nebreda AR. The EMBO journal. 1998 17:5037-47. [PubMed:9724639] [PMC:PMC1170831] Related Antibodies: LS-C18772.

Filtered By: None
Target
cdk1-cdc2 (221)
Reactivity
Human (214)
Mouse (121)
Rat (105)
Bat (5)
Bovine (33)
Chicken (37)
Chimpanzee (12)
Dog (25)
Drosophila (11)
Gibbon (9)
Goat (20)
Guinea pig (23)
Hamster (17)
Horse (23)
Mink (2)
Monkey (32)
Orangutan (12)
Pig (24)
Primate (1)
Rabbit (24)
Rodent (7)
Sheep (22)
Xenopus (34)
Zebrafish (15)
Application
IHC (45)
IHC-Fr (5)
IHC-P (47)
WB (206)
Flo (13)
DB (3)
ELISA (99)
Func (5)
ICC (9)
IF (36)
IP (40)
PLA (1)
Host
rabbit (167)
mouse (54)
Isotype
IgG (114)
IgG1 (8)
IgG1,k (3)
IgG2a (21)
IgG2a,k (15)
IgG2a,l (1)
IgG2b,k (1)
Clonality
monoclonal mc (54)
polyclonal pc (167)
Clone
1644CT107.30.27 (1)
1A4-1A9 (1)
1C7 (1)
2130C1a (2)
26E11 (1)
2G9 (1)
5A6 (1)
5F6 (1)
8C5A6 (1)
8C5A7F10 (1)
8F1 (1)
A17.1.1 (3)
CDK1/873 (2)
CDVC2-1 (2)
IL-16 (1)
IMD-34 (4)
POH-1 (8)
Format
AP Conjugated (11)
APC Conjugated (11)
Azide-free (11)
Biotin Conjugated (20)
FITC Conjugated (19)
HRP Conjugated (16)
Magnetic beads Conjugated (1)
PE Conjugated (11)
Sepharose Conjugated (1)
Unconjugated (131)
Epitope
C-Terminus (17)
Ser39 (13)
pThr161 (13)
pTyr15 (11)
Thr14 (8)
aa220-249 (7)
aa238-267 (7)
aa269-297 (7)
aa8-37 (7)
pThr14 (5)
N-Terminus (4)
aa143-192 (4)
aa718-767 (4)
aa13-297 (3)
aa59-181 (3)
aa59-182 (3)
Internal (2)
Tyr15 (2)
pSer39 (2)
Asn133 (1)
Glu8 (1)
Lys9 (1)
Thr161 (1)
Tyr19 (1)
aa1-29 (1)
aa1-297 (1)
aa1-50 (1)
aa1-80 (1)
aa100-180 (1)
aa101-150 (1)
aa17-21 (1)
aa213-241 (1)
aa225-275 (1)
aa230-260 (1)
aa263-287 (1)
aa268-297 (1)
aa279-297 (1)
aa66-297 (1)
aa70-150 (1)
aa84-133 (1)
pSer/Thr (1)
pThr14/Tyr15 (1)
pTyr14 (1)
Publications
No (220)
Yes (1)
Showing 1-25 out of 221 results
Anti-CDK1 / CDC2 Antibody (Tyr15) IHC-plus™ LS-B1180

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
IF IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (Thr161) IHC-plus™ LS-B1179

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
IF IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone 26E11) IHC-plus™ LS-B7092

Mouse Monoclonal [clone 26E11] (IgG2a,k) to Human CDK1 / CDC2
Mouse, Rat, Human
ELISA IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone POH-1) LS-C18772

Mouse Monoclonal [clone POH-1] to Human CDK1 / CDC2
Mouse, Rat, Human
IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Ser/Thr) LS-C14410

Mouse Monoclonal (IgG2a) to Xenopus CDK1 / CDC2
Xenopus, Chicken, Mouse, Rat, Human
Func IF IHC-Fr IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Thr14/Tyr15) IHC-plus™ LS-B6130

Rabbit Polyclonal to Human CDK1 / CDC2
Mouse, Rat, Human
IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone POH-1) IHC-plus™ LS-B3726

Mouse Monoclonal [clone POH-1] (IgG2a) to Human CDK1 / CDC2
Bovine, Human, Primate
ICC IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone 5F6) IHC-plus™ LS-B14793

Mouse Monoclonal [clone 5F6] (IgG2b,k) to Human CDK1 / CDC2
Rabbit, Mouse, Rat, Human
IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone POH-1) IHC-plus™ LS-B3669

Mouse Monoclonal [clone POH-1] to Human CDK1 / CDC2
Human
IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (C-Terminus) LS-C5893

Mouse Monoclonal (IgG2a,k) to Xenopus CDK1 / CDC2
Xenopus, Chicken, Rodent, Human
ELISA Func IHC-Fr IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Thr161) LS-C123206

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Chicken, Zebrafish, Horse, Rat, Bovine, Mouse, Dog, Human
IHC WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Tyr15) LS-C117314

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
ELISA WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (C-Terminus, clone IMD-34) LS-C171234

Mouse Monoclonal [clone IMD-34] (IgG2a) to Xenopus CDK1 / CDC2
Xenopus, Chicken, Mouse, Human
IHC-Fr IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone 2G9) LS-C169331

Mouse Monoclonal [clone 2G9] (IgG1) to Human CDK1 / CDC2
Mouse, Rat, Human, Monkey
ELISA ICC IF IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone 1A4-1A9) LS-C133063

Mouse Monoclonal [clone 1A4-1A9] (IgG1,k) to Human CDK1 / CDC2
Human
ELISA IF IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone POH-1) LS-C357826

Mouse Monoclonal [clone POH-1] (IgG2a,k) to Human CDK1 / CDC2
Bovine, Mink, Human, Monkey
ELISA Flo IF IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (clone POH-1, Azide-free) LS-C389521

Mouse Monoclonal [clone POH-1] (IgG2a,k) to Human CDK1 / CDC2
Bovine, Mink, Human, Monkey
ELISA Flo IF IHC-P IP WB
Unconjugated, Azide-free
Anti-CDK1 / CDC2 Antibody (clone 8C5A6) LS-C109152

Mouse Monoclonal [clone 8C5A6] (IgG1) to Human CDK1 / CDC2
Human
ELISA IF IHC WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Tyr15) LS-C178124

Rabbit Polyclonal to Human CDK1 / CDC2
Mouse, Rat, Human
IHC-P
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Thr161) LS-C351972

Rabbit Polyclonal to Human CDK1 / CDC2
Chicken, Zebrafish, Bovine, Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (Internal) LS-C351970

Rabbit Polyclonal to Human CDK1 / CDC2
Mouse, Dog, Bovine, Rat, Pig, Human, Monkey
ICC IF IHC-P IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (aa70-150) LS-C382669

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (phospho-Thr161) LS-C5887

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
ELISA ICC IF IP WB
Unconjugated
Anti-CDK1 / CDC2 Antibody LS-C330847

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-CDK1 / CDC2 Antibody (C-Terminus) IHC-plus™ LS-B5295

Rabbit Polyclonal (IgG) to Human CDK1 / CDC2
Mouse, Rat, Human
IHC-P IP WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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