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CDH8 / Cadherin 8
cadherin 8, type 2
CDH8 / Cadherin 8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.
| Gene Name: | cadherin 8, type 2 |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | CDH8, Cadherin 8, type 2, Nbla04261, Cadherin-8 |
| Target Sequences: | NM_001796 NP_001787.2 P55286 |
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