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CDH12 / Cadherin 12

cadherin 12, type 2 (N-cadherin 2)

CDH12 / Cadherin 12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Gene Name: cadherin 12, type 2 (N-cadherin 2)
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: CDH12, Brain cadherin, Cadherin-12, Br-cadherin, Brain-cadherin, Cadherin, neural type, 2, CDHB, N-cadherin 2, Neural type cadherin 2, Neuronal cadherin 2
Target Sequences: NM_004061 NP_004052.2 P55289

Publications (1)

1
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer10<sup> Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. simon.knott@cshs.org12<sup> Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. dan.theodorescu@cshs.org. Kenneth H Gouin rd # , Nathan Ing # , Jasmine T Plummer , Charles J Rosser , Bassem Ben Cheikh , Catherine Oh , Stephanie S Chen , Keith Syson Chan , Hideki Furuya , Warren G Tourtellotte , Simon R V Knott , Dan Theodorescu. Nature communications. 2021 Aug;12:4906. [Full Text Article] [PubMed:34385456] [PMC:PMC8361097] Related Antibodies: LS-B11408.

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Antibodies (25)
Proteins (6)
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Primary (25)
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CDH12 / Cadherin 12 (32)
Human (25)
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rabbit (23)
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CDH12 / Cadherin 12 Antibody - Anti-CDH12 / Cadherin 12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CDH12 / Cadherin 12 Antibody - Anti-CDH12 / Cadherin 12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
CDH12 / Cadherin 12 Antibody - Anti-CDH12 / Cadherin 12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CDH12 / Cadherin 12 Antibody - Anti-CDH12 / Cadherin 12 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
CDH12 / Cadherin 12 Protein - 12.5% SDS-PAGE of human CDH12 stained with Coomassie Blue
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Wheat Germ Extract
GST
114.7 kDa
2 µg/$439
CDH12 / Cadherin 12 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa62-90) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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CDH12 / Cadherin 12 Mouse anti-Human Monoclonal (1B4) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$423
CDH12 / Cadherin 12 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using CDH12 Polyclonal Antibody at dilution of 1:60(×200)
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CDH12 / Cadherin 12 Antibody - Western blot analysis of CDH12 expression in Jurkat cells lysate. The lane on the left is treated with the antigen-specific peptide.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CDH12 / Cadherin 12 Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
CDH12 / Cadherin 12 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa324-373) Antibody
Human
WB
Unconjugated
100 µl/$424
CDH12 / Cadherin 12 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa324-373) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
CDH12 / Cadherin 12 Antibody - 721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal (aa324-373) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
CDH12 / Cadherin 12 Antibody - Western blot analysis of extracts of various cell lines, using CDH12 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CDH12 / Cadherin 12 Antibody - Anti-CDH12 rabbit polyclonal antibody at 1:500 dilution. Lane A: Jurkat Whole Cell Lysate. Lane B: U 251MG Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 88 kDa. Observed band size: 88 kDa.
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CDH12 / Cadherin 12 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$412
Viewing 1-25 of 32 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).