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CDCA8 / Borealin
cell division cycle associated 8
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
| Gene Name: | cell division cycle associated 8 |
| Synonyms: | CDCA8, Borealin, Dasra B, Dasra-B, DasraB, HDasra-B, PESCRG3, BOR, MESRGP |
| Target Sequences: | NM_018101 NP_060571.1 Q53HL2 |
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