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CDCA5 / Sororin

cell division cycle associated 5

Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.

Gene Name:	cell division cycle associated 5
Synonyms:	CDCA5, p35, Sororin
Target Sequences:	NM_080668 NP_542399.1 Q96FF9

Publications (1)

The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends. Gelot C, Guirouilh-Barbat J, Le Guen T, Dardillac E, Chailleux C, Canitrot Y, Lopez BS. Molecular cell. 2016 61:15-26. (WB, IP; Human) [Full Text Article] [PubMed:26687679] Related Antibodies: LS-B9756.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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